2. Recombinant Proteins
  3. Kinases
  4. STE

STE

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Cat. No. Product Name / Synonyms Species Source Image
  • HY-P73282
    LOK Protein, Human (Active, His)

    Serine/threonine-protein kinase 10; STK10; LOK

    		Human E. coli
    LOK is an important serine/threonine protein kinase that significantly regulates lymphocyte migration by phosphorylating MSN and potentially PLK1. It acts as a negative regulator of MAP3K1/MEKK1. LOK Protein, Human (His) is the recombinant human-derived LOK protein, expressed by E. coli , with N-His labeled tag.
    (1)
  • HY-P74741
    MST4/STK26 Protein, Human (Active, sf9, GST)

    Serine/threonine-protein kinase 26; MST-4; STK26; MASK

    		Human Sf9 insect cells
    MST4/STK26 is a kinase that mediates cell growth, regulates apoptosis, and, together with STK24, is involved in negatively affecting Golgi reorientation during RHO-triggered polarized cell migration. MST4/STK26 enhances autophagic flux by phosphorylating ATG4B at 'Ser-383'. MST4/STK26 Protein, Human (sf9, GST) is the recombinant human-derived MST4/STK26 protein, expressed by Sf9 insect cells , with GST labeled tag.
  • HY-P74742
    MST1/STK4 Protein, Human (Active, sf9, His)

    Serine/threonine-protein kinase 4; MST1/N; MST1/C; STK4; KRS2

    		Human Sf9 insect cells
    MST1/STK4 protein is a stress-activated kinase that is critical in the Hippo signaling pathway and can induce apoptosis and regulate hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, causing chromatin condensation and DNA fragmentation. MST1/STK4 Protein, Human (sf9, His) is the recombinant human-derived MST1/STK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.
    (1)
  • HY-P77222
    TAOK3 Protein, Human (Active, sf9, His)

    Serine/threonine-protein kinase TAO3; JNK/SAPK-inhibitory kinase; DPK; JIK; KDS; MAP3K18

    		Human Sf9 insect cells
    TAOK3, a kinase, regulates the p38/MAPK14 and MAPK8/JNK cascades. It activates the p38/MAPK14 cascade, particularly in DNA damage-induced G2/M transition, likely through MAP2K3 and MAP2K6 phosphorylation. TAOK3 inhibits basal MAPK8/JNK activity and dampens its response to epidermal growth factor. These functions showcase TAOK3's role in coordinating cellular responses to DNA damage and growth factor signaling. TAOK3 Protein, Human (sf9, His) is the recombinant human-derived TAOK3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
    (1)
  • HY-P73811
    MKK6 Protein, Human (Active, S207D, T211D, sf9, His-GST)

    MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3

    		Human Sf9 insect cells
    The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (S207D, T211D, sf9, His-GST) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
    (1)
  • HY-P71530
    PAK1 Protein, Human (His-SUMO)

    Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1 ; p65-PAK; PAK1

    		Human E. coli
    PAK1 is a dynamic protein kinase that plays an important role in multiple intracellular signaling pathways, affecting cytoskeletal dynamics, adhesion, migration, proliferation, apoptosis, mitosis, and vesicle trafficking. Multifunctional PAK1 directly phosphorylates BAD to provide antiapoptotic cell protection. PAK1 Protein, Human (His-SUMO) is the recombinant human-derived PAK1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.
  • HY-P73825
    MEK1 Protein, Mouse (Inactive, sf9, His-GST)

    Dual specificity mitogen-activated protein kinase kinase 1; MAPKK 1; MEK 1; Map2k1

    		Mouse Sf9 insect cells
    The MEK1 protein is a dual-specificity kinase that plays a crucial role in the MAP kinase pathway.MEK1 regulates various cellular processes such as growth, adhesion, survival, and differentiation, as well as transcription, metabolism, and cytoskeletal rearrangements.MEK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived MEK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
  • HY-P701645
    TNIK Protein, Human (sf9, His)

    TNIK; TRAF2 and NCK-interacting protein kinase

    		Human Sf9 insect cells
    TNIK protein is a key activator of the Wnt signaling pathway and regulates gene expression by phosphorylating TCF4/TCF7L2 at the promoter of Wnt target genes. TNIK is located upstream of the JUN N-terminal pathway and contributes to the complex Wnt signaling cascade. TNIK Protein, Human (sf9, His) is the recombinant human-derived TNIK protein, expressed by sf9 insect cells , with N-8*His labeled tag.
  • HY-P701646
    TNIK Protein, Human (Active, sf9)

    TNIK; TRAF2 and NCK-interacting protein kinase

    		Human Sf9 insect cells
    TNIK protein is a key activator of the Wnt signaling pathway and regulates gene expression by phosphorylating TCF4/TCF7L2 at the promoter of Wnt target genes. TNIK is located upstream of the JUN N-terminal pathway and contributes to the complex Wnt signaling cascade. TNIK Protein, Human (sf9) is the recombinant human-derived TNIK protein, expressed by sf9 insect cells , with tag free.
  • HY-P701705
    ASK1 Protein, Human (His)

    MAP3K5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5

    		Human E. coli
    ASK1 protein is a key serine/threonine kinase in the MAP kinase pathway, coordinating cellular responses to environmental changes and affecting cell fate, differentiation, and survival. ASK1 is a key player in apoptosis and promotes mitochondria-dependent caspase activation. ASK1 Protein, Human (His) is the recombinant human-derived ASK1 protein, expressed by E. coli , with C-6*His labeled tag.
  • HY-P701732
    PAK6 Protein, Human

    PAK6; Serine/threonine-protein kinase PAK 6; PAK-5; p21-activated kinase 6; PAK-6

    		Human E. coli
    PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human is the recombinant human-derived PAK6 protein, expressed by E. coli , with tag free.
  • HY-P701821
    MST2 Protein, Human (Active, sf9, GST)

    STK3; Serine/threonine-protein kinase 3; Mammalian STE20-like protein kinase 2; MST-2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1

    		Human Sf9 insect cells
    MST2 protein is a stress-activated kinase that plays an important role in the Hippo signaling pathway, regulates organ size and inhibits tumors. Cleaved MST2 enters the nucleus and induces apoptosis through chromatin condensation. MST2 Protein, Human (sf9, GST) is the recombinant human-derived MST2 protein, expressed by sf9 insect cells , with N-GST labeled tag.
  • HY-P702743
    MAP4K4 Protein, Human (Active, sf9, GST)

    MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4; FLH21957; hepatocyte progenitor kinase like/germinal center kinase like kinase; HGK; HPK/GCK like kinase; NIK

    		Human Sf9 insect cells
    MAP4K4 Protein, Human (sf9, GST) is the recombinant human-derived MAP4K4, expressed by Sf9 insect cells , with GST labeled tag. ,
  • HY-P702747
    PAK4 Protein, Human (Active, His)

    PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs

    		Human E. coli
    PAK4 is an important serine/threonine kinase that affects cytoskeletal regulation, cell migration, growth, and survival through multiple pathways. Activation triggered by various effectors induces autophosphorylation, targeting proteins such as SSH1 and LIMK1 to regulate cofilin activity and stabilize actin filaments. PAK4 Protein, Human (His) is the recombinant human-derived PAK4, expressed by E. coli, with N-His labeled tag.
  • HY-P702750
    MST3/STK24 Protein, Human (Active, sf9, GST)

    STK24; serine/threonine kinase 24; MST3; STK3; MST3B; STE20; HEL-S-95

    		Human Sf9 insect cells
    MST3/STK24 is a serine/threonine protein kinase that induces apoptosis in response to stress and caspase activation. It mediates oxidative stress-induced cell death by regulating the phosphorylation of JNK1-JNK2 and p38 during oxidative stress. MST3/STK24 Protein, Human (sf9, GST) is the recombinant human-derived MST3/STK24, expressed by Sf9 insect cells, with GST labeled tag.
  • HY-P703586
    MEK1 Protein, Human (Inactive, sf9, His)

    MEK1; PRKMK1

    		Human Sf9 insect cells
    MEK1 Protein, Human (Inactive, sf9, His) is the recombinant human-derived MEK1, expressed by sf9 insect cells , with His labeled tag. ,
  • HY-P704011
    MEK1 Protein, Human (Active, Phosphorylated, sf9, His)

    MEK1; PRKMK1

    		Human Sf9 insect cells
    MEK1 Protein, Human (Active, Phosphorylated, sf9, His) is the recombinant human-derived MEK1 protein, expressed by Sf9 insect cells, with N-6*His tag.
  • HY-P73811A
    MKK6 Protein, Human (S207D, T211D, sf9, His)

    MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3

    		Human Sf9 insect cells
    The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (S207D, T211D, sf9, His) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells, with N-6*His labeled tag.
    (2)
  • HY-P74746
    MKK6 Protein, Human (sf9)

    Dual specificity mitogen-activated protein kinase kinase 6; MAPKK 6; MEK 6; SAPKK3; MAP2K6

    		Human Sf9 insect cells
    The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells, with tag free and additional two amino acids (Gly & Pro) at the N-terminus.
  • HY-P74755
    MEK2 Protein, Human (Active, sf9, GST)

    Dual specificity mitogen-activated protein kinase kinase 2; MAPKK 2; MEK 2

    		Human Sf9 insect cells
    The MEK2 protein phosphorylates threonine and tyrosine residues in a Thr-Glu-Tyr sequence of MAP kinases. It activates ERK1 and ERK2 MAP kinases and BRAF through a KSR1 or KSR2-dependent mechanism. By binding to KSR1 or KSR2, it enables dimerization and activation of BRAF by releasing inhibitory intramolecular interactions (PubMed:29433126). MEK2 Protein, Human (sf9, GST) is the recombinant human-derived MEK2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
Cat. No. Product Name Effect Purity