L-NMMA (Synonyms: Tilarginine; Methylarginine)

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L-NMMA (Tilarginine; Methylarginine) competitively antagonizes L-arginine, and thus inhibits production of nitric oxide (NO). L-NMMA is utilized as NO synthase antagonist in experimental settings.

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L-NMMA Chemical Structure

CAS No. : 17035-90-4

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Other In-stock Forms of L-NMMA:

L-NMMA acetate

Other Forms of L-NMMA:

L-NMMA acetate In-stock

5 Publications Citing Use of MCE L-NMMA

Cell Viability Assay

: L-NMMA purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173. [Abstract]; L-NMMA acetate (200 μM; 48 h) leads to elevating ammonia and inhibiting CD8⁺ T_M cell induction, in parallel with the inhibition of NO production.

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Description	L-NMMA (Tilarginine; Methylarginine) competitively antagonizes L-arginine, and thus inhibits production of nitric oxide (NO). L-NMMA is utilized as NO synthase antagonist in experimental settings^[1].
Molecular Weight	188.23
Formula	C₇H₁₆N₄O₂
CAS No.	17035-90-4
SMILES	OC([C@@H](N)CCCNC(NC)=N)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Frey C, et al., L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269(42):26083-91. [Content Brief]

L-NMMA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-NMMA17035-90-4Tilarginine MethylarginineNO SynthaseNitric oxide synthasesNOScompetitiveInhibitorinhibitorinhibit

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L-NMMA (Synonyms: Tilarginine; Methylarginine)

Other Forms of L-NMMA:

L-NMMA Related Antibodies

5 Publications Citing Use of MCE L-NMMA

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•Related Small Molecules:

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Biological Activity

Purity & Documentation

References

Customer Review