Search Result

Results for "

MMP inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MMP (155) Akt (6) Aminopeptidase (1) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (9) AP-1 (2) Apoptosis (31) Atg8/LC3 (1) Autophagy (5) Bacterial (14) Caspase (1) CDK (1) Chloride Channel (2) Cholinesterase (ChE) (2) COX (5) Deubiquitinase (1) Drug Metabolite (1) EGFR (1) ERK (1) FAK (3) Fungal (2) Glucocorticoid Receptor (2) HIV (3) HIV Integrase (1) HIV Protease (3) HSV (1) iGluR (1) Interleukin Related (1) Isotope-Labeled Compounds (3) JNK (1) MALT1 (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) mTOR (2) NF-κB (8) Nucleoside Antimetabolite/Analog (1) Oxidative Phosphorylation (2) P-glycoprotein (1) p38 MAPK (4) Parasite (8) PI3K (3) PKC (1) Procollagen C Proteinase (1) Proteasome (1) Pyroptosis (1) Ras (1) Reactive Oxygen Species (5) SARS-CoV (4) Src (1) TNF Receptor (5) Toll-like Receptor (TLR) (1) VEGFR (1)
By Research Areas:	Cancer (116) Cardiovascular Disease (14) Endocrinology (5) Infection (20) Inflammation/Immunology (57) Metabolic Disease (7) Neurological Disease (9)

By Targets:

MMP (155)

Akt (6)

Aminopeptidase (1)

Amyloid-β (1)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (9)

AP-1 (2)

Apoptosis (31)

Atg8/LC3 (1)

Autophagy (5)

Bacterial (14)

Caspase (1)

CDK (1)

Chloride Channel (2)

Cholinesterase (ChE) (2)

COX (5)

Deubiquitinase (1)

Drug Metabolite (1)

EGFR (1)

ERK (1)

FAK (3)

Fungal (2)

Glucocorticoid Receptor (2)

HIV (3)

HIV Integrase (1)

HIV Protease (3)

HSV (1)

iGluR (1)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

JNK (1)

MALT1 (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (2)

mTOR (2)

NF-κB (8)

Nucleoside Antimetabolite/Analog (1)

Oxidative Phosphorylation (2)

P-glycoprotein (1)

p38 MAPK (4)

Parasite (8)

PI3K (3)

PKC (1)

Procollagen C Proteinase (1)

Proteasome (1)

Pyroptosis (1)

Ras (1)

Reactive Oxygen Species (5)

SARS-CoV (4)

Src (1)

TNF Receptor (5)

Toll-like Receptor (TLR) (1)

VEGFR (1)

By Research Areas:

Cancer (116)

Cardiovascular Disease (14)

Endocrinology (5)

Infection (20)

Inflammation/Immunology (57)

Metabolic Disease (7)

Neurological Disease (9)

188

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: MMP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128026

MMP-9/MMP-13 Inhibitor I	MMP	Inflammation/Immunology
MMP-9/MMP-13 Inhibitor I is a potent *MMP-9* and *MMP-13* inhibitor with IC₅₀s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs .

HY-112546

MMP-2 Inhibitor I

MMP Cancer

MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor with a K_i of 1.7 μM .

MMP-2 Inhibitor I	MMP	Cancer
MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor with a K_i of 1.7 μM .

HY-119423

MMP Inhibitor II	MMP	Cancer
MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC₅₀ values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively .

HY-128133

MMP-8 inhibitor-1

MMP8-I
MMP Cancer

MMP-8 inhibitor-1 (compound 21), a hydroxamic acid derivative, is a potent MMP-8 inhibitor without significant oral bioavailability .

MMP-8 inhibitor-1 MMP8-I	MMP	Cancer
MMP-8 inhibitor-1 (compound 21), a hydroxamic acid derivative, is a potent *MMP-8* inhibitor without significant oral bioavailability .

HY-130076

MMP-2 Inhibitor II	MMP	Cancer
MMP-2 Inhibitor II (compound 2) is a selective *MMP-2* inhibitor. The Kinetic parameters for MMP inhibition are 2.4 μM (MMP-2), 45 μM (MMP-1), and 379 μM (MMP-7), respectively .

HY-114418

MMP3 inhibitor 1

1 Publications Verification

MMP Cancer

MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC₅₀ of 1 nM .
HY-P2166

MMP3 inhibitor 3

MMP Cancer

MMP3 inhibitor 3 is an inhibitor of MMP3. MMP3 inhibitor 3 can used to study breast cancer .

MMP3 inhibitor 1 1 Publications Verification	MMP	Cancer
MMP3 inhibitor 1 is a potent and highly selective *MMP-3* inhibitor with an IC₅₀ of 1 nM .

MMP3 inhibitor 3	MMP	Cancer
MMP3 inhibitor 3 is an inhibitor of *MMP3. MMP3 inhibitor* 3 can used to study breast cancer .

HY-147745

MMP2-IN-2	MMP	Cancer
MMP2-IN-2 (compound 42) is a potent and selective *MMP-2* (matrix metalloproteinases) inhibitor, with an IC₅₀ of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against *MMP-13, MMP-9* and *MMP-8, with IC₅₀* values of 12, 23.3, and 25 μM, respectively .

HY-14240

PG 116800 PG 530742; PGE 530742; PGE 7113313	MMP	Inflammation/Immunology
PG 116800 (PG 530742) is an orally avtive *MMP* inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research .

HY-156430

MMP-7-IN-3	MMP	Cancer
MMP-7-IN-3 is a potent and selective inhibitor of *MMP-7. MMP*-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction .

HY-162038

RXP03

MMP Others

RXP03 is a MMPs inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .

RXP03	MMP	Others
RXP03 is a *MMPs* inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .

HY-13564

Batimastat 5+ Cited Publications BB94	MMP	Cancer
Batimastat is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-13564A

Batimastat sodium salt BB-94 sodium salt	MMP	Cancer
Batimastat sodium salt is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-15768

Ilomastat 35+ Cited Publications GM6001; Galardin	MMP	Cancer
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC₅₀s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a K_i of 0.4 nM for human skin fibroblast collagenase (MMP-1).

HY-107639

UK-370106	MMP	Inflammation/Immunology
UK-370106 is a potent and highly selective *MMP-3* (IC₅₀ of 23 nM) and *MMP-12* (IC₅₀ of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [ ³H]-fibronectin by *MMP-3* (IC₅₀ of 320 nM) and has little effect on keratinocyte migration in vitro .

HY-146218

MMP-9-IN-5	MMP Akt Apoptosis	Cancer
MMP-9-IN-5 is a *MMP-9* inhibitor (IC₅₀: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits _AKT activity (IC₅₀: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers .

HY-146216

MMP-9-IN-3	MMP Akt Apoptosis	Cancer
MMP-9-IN-3 is a *MMP-9* inhibitor (IC₅₀: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC₅₀: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers .

HY-107394

UK 356618 4 Publications Verification	MMP	Inflammation/Immunology Cancer
UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC₅₀ of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with *MMP-3* .

HY-W011085

CP-471474	MMP	Inflammation/Immunology
CP-471474 is an orally active and pan *MMP* inhibitor, with IC₅₀ values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively .

HY-146217

MMP-9-IN-4	MMP Akt Apoptosis	Cancer
MMP-9-IN-4 is a *MMP-9* inhibitor (IC₅₀: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits _AKT activity (IC₅₀: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers .

HY-116302

MMP-9-IN-9	MMP	Neurological Disease Inflammation/Immunology
MMP-9-IN-9 (compound 4f) is a slective *MMP-9* inhibitor with an IC₅₀ of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects .

HY-12170

Prinomastat 2 Publications Verification AG3340; KB-R9896	MMP Apoptosis	Cancer
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for *MMP-1, MMP-3* and *MMP-9, respectively. Prinomastat inhibits* *MMP-2, MMP-3, MMP-13* and *MMP-9* with K_is of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity .

HY-12170A

Prinomastat hydrochloride 2 Publications Verification AG3340 hydrochloride; KB-R9896 hydrochloride	MMP Apoptosis	Cancer
Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for *MMP-1, MMP-3* and *MMP-9, respectively. Prinomastat hydrochloride inhibits* *MMP-2, MMP-3, MMP-13* and *MMP-9* with K_is of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat hydrochloride can cross blood-brain barrier. Antitumor avtivity .

HY-112160

XL-784 free base	MMP	Cardiovascular Disease
XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-19485

XL-784 1 Publications Verification	MMP	Cardiovascular Disease
XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13，respectively.

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-147867

MMP-2/9-IN-1	MMP	Cancer
MMP-2/9-IN-1 (Compound 4a) is a potent dual *MMP-2* and *MMP-9* inhibitor with IC₅₀ values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation .

HY-135232

MMP-9-IN-1 5 Publications Verification	MMP	Cancer
MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs .

HY-18694

CGS 27023A	MMP	Inflammation/Immunology
CGS 27023A is a non-peptidic and orally active *MMP* inhibitor with the K_i values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis .

HY-116399

MMP-2/MMP-9-IN-1	MMP	Cancer
MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and *MMP-2) inhibitor* with IC₅₀s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer .

HY-N1463

Luteolin 7-O-glucuronide 1 Publications Verification Luteolin 7-glucuronide	MMP	Neurological Disease Inflammation/Immunology
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-114785

BPHA	MMP	Cancer
BPHA is a potent and orally active *MMP-2, MMP-9* and *MMP-14* inhibitor with IC₅₀s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC₅₀s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects .

HY-110046

CL-82198 hydrochloride	MMP	Others
CL-82198 hydrochloride is a selective inhibitor of *MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP*-9, and TACE .

HY-154868

MMP-13-IN-1	MMP	Cardiovascular Disease Cancer
MMP-13-IN-1 is a potent and selective inhibitor of *MMP-13* with a IC₅₀ value of 16 nM. MMP-13-in-1 can be used for atherosclerosis research .

HY-N1454

Apigenin-7-glucuronide 1 Publications Verification Apigenin 7-O-glucuronide	MMP	Cancer
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-147746

MMP2-IN-3	MMP	Cancer
MMP2-IN-3 (compound 2) is a potent *MMP-2* (matrix metalloproteinases) inhibitor, with an IC₅₀ of 31 μM. MMP2-IN-3 also shows inhibitory activity against *MMP-9* and *MMP-8, with IC₅₀* values of 26.6, and 32 μM, respectively .

HY-151540

MMP-7-IN-1	MMP	Cancer
MMP-7-IN-1 is a potent and selective inhibitor of *MMP-7* over MMP-1, -2, -3, -8, -9, -13 with an IC₅₀ value of 10 nM. MMP-7 is a potential target for diseases including cancer and fibrosis .

HY-152030

Tubulin/MMP-IN-2	Microtubule/Tubulin MMP Apoptosis	Cancer
Tubulin/MMP-IN-2 is dual inhibitor of tubulin and matrix metalloproteinases. Tubulin/MMP-IN-2 can strongly inhibit tubulin polymerization and induces cell apoptosis. Tubulin/MMP-IN-2 has inhibitory activities against MMP-2, MMP-3 and MMP-9 with IC₅₀ values of 24.95 μM, 31.60 μM and 22.37 μM, respectively. Tubulin/MMP-IN-2 can be used for the research of cancer .

HY-N10176

D-Isofloridoside	Reactive Oxygen Species MMP	Cardiovascular Disease
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-153913

MMP-9-IN-7	MMP	Inflammation/Immunology
MMP-9-IN-7 is a potent *MMP9* inhibitor with an IC₅₀ of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research .

HY-114396

BR351

MMP Cancer

BR351 is a brain penetrant MMP inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively .
HY-152092

MMP-1-IN-1

MMP Cancer

MMP-1-IN-1 (Compound 6) is a highly potent MMP-1 inhibitor with an IC₅₀ of 0.034 μM .
HY-14155

MMP145

MMP Inflammation/Immunology

MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch .

BR351	MMP	Cancer
BR351 is a brain penetrant *MMP* inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively .

MMP-1-IN-1	MMP	Cancer
MMP-1-IN-1 (Compound 6) is a highly potent *MMP-1* inhibitor with an IC₅₀ of 0.034 μM .

MMP145	MMP	Inflammation/Immunology
MMP145 (compound 27) is a potent, selective and orally active *MMP-12* inhibitor. MMP145 is effective in inflammation and asthma reasearch .

HY-161285

MMP-9/10-IN-2	MMP	Cancer
MMP-9/10-IN-2 (compound 6e) is a potent inhibitor of *MMP10 and MMP9, with IC₅₀* of 0.076 μM for *MMP*10, and 93.18% inhibition at 0.5 μM for *MMP9. MMP*-9/10-IN-2 plays an important role in anti-tumor .

HY-117970

MMPI-1154	MMP	Cardiovascular Disease
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) *MMP-2* inhibitor(IC₅₀=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC₅₀s of 1.8 μM,10 μM, and 13 μM, respectively .

HY-124373A

(R)-ND-336	MMP	Metabolic Disease
(R)-ND-336 is a potent and selective *MMP-9* inhibitor with a K_i of 19 nM. (R)-ND-336 inhibits MMP-2 (K_i=127 nM) and MMP-14 (K_i=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research .

HY-131417

cis-ACCP	MMP	Infection Cardiovascular Disease Inflammation/Immunology Cancer
cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC₅₀ values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases .

HY-113952

Actinonin 4 Publications Verification (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits *MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-114091

PF-00356231 hydrochloride 1 Publications Verification	MMP	Inflammation/Immunology
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase *MMP-12* (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-156430

MMP-7-IN-3	MMP	Cancer
MMP-7-IN-3 is a potent and selective inhibitor of *MMP-7. MMP*-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction .

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-153563

MMP-7-IN-2

MMP Others

MMP-7-IN-2 (compound 16) is a selective inhibitor of MMP7 with an IC₅₀ value of 16 nM .
HY-P2166

MMP3 inhibitor 3

MMP Cancer

MMP3 inhibitor 3 is an inhibitor of MMP3. MMP3 inhibitor 3 can used to study breast cancer .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P0273

Histatin 5

MMP Inflammation/Immunology

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.
HY-P0273A

Histatin 5 TFA

MMP Inflammation/Immunology

Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.
HY-137793

Pro-Leu-Gly-NHOH hydrochloride

MMP Cancer

Pro-Leu-Gly-NHOH hydrochloride is an inhibitor of MMP-8 .

HY-P6183

LXJ-02	Peptides	Cancer
LXJ-02 is a potent inhibitor of EDPs/EBP peptide–protein interaction, with the K_D of 117 μM for EDPs. LXJ-02 activates the macrophage-MMP-12 axis to increase MMP-12 expression and degrade ECM components like elastin .

HY-P5337

Myristoyl tetrapeptide Ala-Ala-Pro-Val	Peptides	Others
Myristoyl tetrapeptide Ala-Ala-Pro-Val is a biological active peptide. (stimulates the expression of ECM proteins and inhibits the expression of metalloproteinases (MMPs))

HY-W011254

Ac-VAD-CHO Ac-Val-Ala-Asp-CHO	Caspase	Cancer
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a *MMP* inhibitor and also attenuates TNF-α processing .

HY-P2641

Peptide 74	MMP	Cancer
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1463

Luteolin 7-O-glucuronide 1 Publications Verification Luteolin 7-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	MMP
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-N1454

Apigenin-7-glucuronide 1 Publications Verification Apigenin 7-O-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	MMP
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-113952

Actinonin 4 Publications Verification (-)-Actinonin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits *MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-N0532

Morroniside	Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	MMP Pyroptosis Apoptosis
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

HY-N10176

D-Isofloridoside	Cardiovascular Disease other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides	Reactive Oxygen Species MMP
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-N7385

Nudol	Orchidaceae Source classification Phenols Polyphenols Plants Epigeneium rotundatum (Lindl.) Summerh.	MMP Apoptosis
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits *MMP-2M* and *MMP-9* activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma .

HY-136699

Excisanin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Baccharis densiflora Wedd.	Others
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-N0262

Cordycepin 5+ Cited Publications 3'-Deoxyadenosine	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Cancer	MMP Bacterial Autophagy Antibiotic
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced *MMP-1* and *MMP-3* expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Plants Solanaceae Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-N12150

Isozedoarondiol	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma zanthorrhiza Roxburgh Zingiberaceae	MMP
Isozedoarondiol can be isolated from the rhizomes of Curcuma xanthorrhiza Roxb. Isozedoarondiol inhibits MMP-1 expression in UVB-treated human keratinocytes .

HY-N6862

Lucideric acid A	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N2117

Isoginkgetin Maximum Cited Publications 12 Publications Verification	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba Disease Research Fields Cancer	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and *MMP-9. Isoginkgetin inhibits* the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-N6860

Lucidenic acid C	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N2199

Sotetsuflavone	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Apoptosis Autophagy
Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits migration and invasion of A549 cells by reversing EMT, and induces cell apoptosis and autophagy. Sotetsuflavone inhibits HIF-1α, VEGF, angiostatin, MMP-9, and MMP-13 expression in A549 cells. Sotetsuflavone also protects mice against Crohn's disease (CD)-like colitis. Sotetsuflavone can be used for research of NSCLC .

HY-77813

Benzyl isothiocyanate	Natural Products Classification of Application Fields Source classification Plants Opiliaceae Disease Research Fields Endocrinology Salvadora persica	Bacterial Apoptosis Antibiotic Parasite
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity . Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells .

HY-118157

3,5,7-Trimethoxyflavone	Structural Classification Flavonoids Flavones Orchidaceae Source classification Plants Nervilia concolor (Blume) Schltr.	Others
3,5,7-Trimethoxyflavone, a flavonoid compound, can inhibit the TNF-α-induced high expression and secretion of MMP-1 by cells. 3,5,7-Trimethoxyflavone can be used to ameliorate skin damage .

HY-N0774

Isofraxidin 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae	COX MMP Toll-like Receptor (TLR)
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits *MMP-7* expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	Structural Classification Source classification Lignans Phenylpropanoids Plants Lauraceae Lindera akoensis Hay.	p38 MAPK AP-1 Bacterial
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv .

HY-N12726

Halociline	Structural Classification Microorganisms Marine natural products Source classification Phenols Marine microorganism	p38 MAPK MMP
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .

HY-N1940

β-Anhydroicaritin 1 Publications Verification	Flavonols Structural Classification Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-N2350

Cynaropicrin	Saussurea costus (Falc.) Lipsch. Classification of Application Fields Source classification Phenols Plants Compositae Disease Research Fields Cancer	MMP NF-κB TNF Receptor
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

HY-N3387

Licoricidin	Natural Products Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Apoptosis NF-κB Akt MMP
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of *MMP-1*, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

HY-134000

Emodic acid NSC624610	Quinones Structural Classification Human Gut Microbiota Metabolites Microorganisms Leguminosae Cercis chinensis Bunge Anthraquinones Source classification Plants Endogenous metabolite	p38 MAPK NF-κB ERK JNK VEGFR MMP
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and *MMP, thereby inhibiting* the invasion and migration potential of cancer cells .

HY-N6013

Aloin(mixture of A&B)	Infection Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields	MMP Bacterial Fungal
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases *(MMPs)* .

HY-N0801

Polygalacic acid	Triterpenes Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	MMP Cholinesterase (ChE)
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits *MMP* expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .

HY-N1401

20(R)-Ginsenoside Rh2 1 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Terpenoids Inflammation/Immunology Disease Research Fields Araliaceae	MMP Apoptosis HSV
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity . 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC₅₀ of 2.77 μM for murine MHV-68 .

HY-N2503

Ginsenoside F4	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	Apoptosis MMP
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-N5072

Desmethylglycitein 1 Publications Verification 4',6,7-Trihydroxyisoflavone	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

Cat. No.	Product Name	Chemical Structure

HY-B0099S

Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4].

HY-77813S

Benzyl isothiocyanate-d7
Benzyl isothiocyanate-d₇ is the deuterium labeled Benzyl isothiocyanate. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].

HY-13571AS1

Beclometasone dipropionate-d10
Beclometasone dipropionate-d₁₀ is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-13571AS

Beclometasone dipropionate-d6
Beclometasone dipropionate-d₆ is deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-W004544S

o-Phenanthroline-d8
o-Phenanthroline-d₈ is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].

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