2. Metabolic Enzyme/Protease
  3. MMP
  4. CGS 27023A

CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis.

For research use only. We do not sell to patients.

CGS 27023A Chemical Structure

CGS 27023A Chemical Structure

CAS No. : 169799-04-6

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CGS 27023A Related Antibodies

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Description

CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis[1].

IC50 & Target

stromelysins 1

43 nM (Ki)

collagenases 1

33 nM (Ki)

MMP-2

20 nM (Ki)

MMP-9

8 nM (Ki)

In Vivo

CGS 27023A (oral gavage, 75 µmol/kg for 10 h) prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

429.92

Formula

C18H24ClN3O5S
CAS No.
SMILES

CC(C)[C@@H](N(S(=O)(C1=CC=C(OC)C=C1)=O)CC2=CC=CN=C2)C(NO)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CGS 27023A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGS 27023A169799-04-6MMPMatrix metalloproteinasesstromelysin-induced cartilage degradationarthritisInhibitorinhibitorinhibit

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CGS 27023A
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HY-18694
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