Search Result
Results for "
Excitability
" in MedChemExpress (MCE) Product Catalog:
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D0127
-
|
Fluorescent Dye
|
Others
|
Merocyanin 540 is a fluorescent membrane probe that selectively stains the membranes of a wide variety of electrically excitable cells, but not those of nonexcitable cells (Ex/Em: 540/580 nm) .
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-
-
- HY-105182
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LY-246708
|
mAChR
|
Neurological Disease
|
Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia .
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-
-
- HY-105182A
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LY 246708 tartrate
|
mAChR
|
Neurological Disease
|
Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia .
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-
-
- HY-D0114
-
-
-
- HY-P1281
-
|
Potassium Channel
|
Neurological Disease
|
Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability .
|
-
-
- HY-108594
-
|
Potassium Channel
|
Metabolic Disease
|
PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability .
|
-
-
- HY-P2707
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α-DTX
|
Sodium Channel
Potassium Channel
|
Others
|
α-Dendrotoxin (α-DTX) is a small molecule peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps). α-Dendrotoxin is also a KV1.1, KV1.2, KV1.6 and ASIC channel blocker. α-Dendrotoxin blocks potassium channels, lowers the threshold of neuronal action potentials, and increases the frequency of action potentials, thereby enhancing neuronal excitability. α-Dendrotoxin can be used in neurotoxicology research .
|
-
-
- HY-P10290
-
|
Neuropeptide Y Receptor
|
Neurological Disease
|
Neuropeptide Y (human) free acid upregulates the adhesiveness of human endothelial cells for leukocytes. Neuropeptide Y belongs to the pancreatic polypeptide family, plays an important role in circadian rhythms, neurogenesis, and neuroprotection, nociception, feeding behavior, energy regulation, neuronal excitability, emotion, cognition, and stress response .
|
-
-
- HY-P1626
-
|
Opioid Receptor
|
Neurological Disease
|
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .
|
-
-
- HY-W013712
-
|
Potassium Channel
|
Neurological Disease
|
GI-530159 is a selective opener of TREK1 and TREK2 potassium channels. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels, with an EC50 of 0.76 μM for TREK1. GI-530159 reduces rat dorsal root ganglion neuron excitability and shows potential analgesic effect .
|
-
-
- HY-149772
-
-
-
- HY-101897
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Fura-2 Acetoxymethyl ester
|
Fluorescent Dye
|
Others
|
Fura-2 AM is a high affinity, intracellular, UV light-excitable and ratiometric fluorescent Ca 2+ indicator.
|
-
-
- HY-146129
-
|
Aldose Reductase
|
Metabolic Disease
|
As an aldose reductase (ALR2) inhibitor, the compound is used to enhance the combination of inhibitory excitability and antioxidant capacity to delay the progress of diabetes complications.
|
-
-
- HY-149863
-
|
Epigenetic Reader Domain
|
Neurological Disease
|
DDO-8926 is a potent and selective BET inhibitor that can significantly reduce mechanical hypersensitivity by inhibiting the expression of pro-inflammatory cytokines and reducing excitability for neuropathic pain research .
|
-
-
- HY-N5060
-
4-Allylanisole
|
Parasite
|
Neurological Disease
|
Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .
|
-
-
- HY-N3711
-
|
JNK
ERK
Apoptosis
|
Neurological Disease
|
Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects .
|
-
-
- HY-D1702
-
|
Fluorescent Dye
|
Others
|
Mag-Fura-2 tetrapotassium is a UV excitable rational fluorescent Mg 2+/Ca 2+ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg 2+ and Ca 2+ concentrations .
|
-
-
- HY-111245
-
-
-
- HY-158183
-
|
Chloride Channel
|
Others
|
NMD670 is an orally active partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. NMD670 increases muscle excitability in response to movement commands, enhances neuromuscular transmission, restores muscle function and improves muscle mobility. NMD670 has a favorable safety profile and improves muscle function in rats in a MG rat model .
|
-
-
- HY-W013576S
-
|
Isotope-Labeled Compounds
|
Cancer
|
Methyl 2-Octynoate-d5 is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .
|
-
-
- HY-148792
-
PRAX-562
|
Sodium Channel
|
Neurological Disease
|
Relutrigine (PRAX-562) is an orally active inhibitor of persistent sodium channel. Relutrigine potently and preferentially inhibits persistent INa induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC50 values of 141 nM and 75 nM, respectively. Relutrigine exhibits potent use-dependent block and reduces neuronal intrinsic excitability. Relutrigine has effective anticonvulsant activity .
|
-
-
- HY-136784
-
|
Fluorescent Dye
|
Others
|
Rhod-2 (potassium salt) is a water-soluble, red fluorescent calcium indicator. It exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators fura-2 and indo-1 (HY-D0121), there is no accompanying spectral shift.
|
-
-
- HY-14856
-
PD 0200390
|
GABA Receptor
|
Neurological Disease
|
Atagabalin (PD 0200390) is a selective GABA (gamma-aminobutyric acid) receptor agonist with antianxiety and sedative effects. Atagabalin enhances the activity of the GABA receptor by binding to the α2δ subunit of the GABA receptor, thereby increasing the GABA mediated inhibition. This enhancement results in reduced excitability of neurons, helping to reduce anxiety and improve sleep. Atagabalin can be used to study neuropsychiatric disorders, anxiety or sleep disorders .
|
-
-
- HY-108578
-
|
Potassium Channel
|
Neurological Disease
|
RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .
|
-
-
- HY-W031620
-
|
Sodium Channel
|
Neurological Disease
|
VGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research .
|
-
-
- HY-135809
-
|
Potassium Channel
|
Neurological Disease
|
A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K + channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC50=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception .
|
-
-
- HY-127004
-
RGH-5002
|
Sodium Channel
|
Others
|
Silperisone hydrochloride is an organosilicone compound similar to tolperisone that has centrally acting muscle relaxant properties. Silperisone (hydrochloride) is a sodium channel protein type 2 alpha channel blocker that blocks sodium and calcium channels in cells, reduces muscle cell excitability and contraction, reduces peripheral tone, and acts as a muscle relaxant and peripheral vascular dilator. Silperisone (hydrochloride) is used to study recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, myotonia symptoms, pyramidal tonia syndrome, multiple sclerosis myospasm, and myelitis .
|
-
-
- HY-N6789
-
KT5720
3 Publications Verification
|
PKA
|
Neurological Disease
Cancer
|
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC50=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 + concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases .
|
-
-
- HY-B1751H
-
|
Sodium Channel
Parasite
|
Infection
Cardiovascular Disease
|
Quinidine is a stereoisomer of Quinine (HY-D0143), a natural compound derived from the bark of the South American cinchona tree. Quinidine is one of the earliest known antiarrhythmic agents and is available as a Class 1a antiarrhythmic and antimalarial drug. Quinidine inhibits the rapid inward sodium current, resulting in the suppression of action potential phase 0. This mechanism suppresses the excitability of the heart muscle, ultimately leading to longer duration of action potentials and reduced automaticity. Quinidine shows a "use-dependent blocking" effect on the rapidly inward sodium current, meaning that the drug's effects increases at higher heart rates and decreases at lower heart rates.Quinidine can be used in the study of Plasmodium falciparum malaria and ventricular arrhythmias .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D0127
-
|
Fluorescent Dyes/Probes
|
Merocyanin 540 is a fluorescent membrane probe that selectively stains the membranes of a wide variety of electrically excitable cells, but not those of nonexcitable cells (Ex/Em: 540/580 nm) .
|
-
- HY-101897
-
Fura-2 Acetoxymethyl ester
|
Fluorescent Dyes/Probes
|
Fura-2 AM is a high affinity, intracellular, UV light-excitable and ratiometric fluorescent Ca 2+ indicator.
|
-
- HY-D0114
-
-
- HY-D1702
-
|
Fluorescent Dyes/Probes
|
Mag-Fura-2 tetrapotassium is a UV excitable rational fluorescent Mg 2+/Ca 2+ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg 2+ and Ca 2+ concentrations .
|
-
- HY-136784
-
|
Fluorescent Dyes/Probes
|
Rhod-2 (potassium salt) is a water-soluble, red fluorescent calcium indicator. It exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators fura-2 and indo-1 (HY-D0121), there is no accompanying spectral shift.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1626
-
|
Opioid Receptor
|
Neurological Disease
|
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .
|
-
- HY-P1281
-
|
Potassium Channel
|
Neurological Disease
|
Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability .
|
-
- HY-P2707
-
α-DTX
|
Sodium Channel
Potassium Channel
|
Others
|
α-Dendrotoxin (α-DTX) is a small molecule peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps). α-Dendrotoxin is also a KV1.1, KV1.2, KV1.6 and ASIC channel blocker. α-Dendrotoxin blocks potassium channels, lowers the threshold of neuronal action potentials, and increases the frequency of action potentials, thereby enhancing neuronal excitability. α-Dendrotoxin can be used in neurotoxicology research .
|
-
- HY-P10290
-
|
Neuropeptide Y Receptor
|
Neurological Disease
|
Neuropeptide Y (human) free acid upregulates the adhesiveness of human endothelial cells for leukocytes. Neuropeptide Y belongs to the pancreatic polypeptide family, plays an important role in circadian rhythms, neurogenesis, and neuroprotection, nociception, feeding behavior, energy regulation, neuronal excitability, emotion, cognition, and stress response .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N5060
-
-
-
- HY-N3711
-
-
-
- HY-B1751H
-
|
Structural Classification
Alkaloids
Source classification
Rubiaceae
Cinchona calisaya Wedd.
Quinoline Alkaloids
Plants
|
Sodium Channel
Parasite
|
Quinidine is a stereoisomer of Quinine (HY-D0143), a natural compound derived from the bark of the South American cinchona tree. Quinidine is one of the earliest known antiarrhythmic agents and is available as a Class 1a antiarrhythmic and antimalarial drug. Quinidine inhibits the rapid inward sodium current, resulting in the suppression of action potential phase 0. This mechanism suppresses the excitability of the heart muscle, ultimately leading to longer duration of action potentials and reduced automaticity. Quinidine shows a "use-dependent blocking" effect on the rapidly inward sodium current, meaning that the drug's effects increases at higher heart rates and decreases at lower heart rates.Quinidine can be used in the study of Plasmodium falciparum malaria and ventricular arrhythmias .
|
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W013576S
-
|
Methyl 2-Octynoate-d5 is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .
|
-
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