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  6. β-Cembrenediol

β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer.

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β-Cembrenediol Chemical Structure

β-Cembrenediol Chemical Structure

CAS No. : 57605-81-9

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β-Cembrenediol Related Antibodies

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Description

β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer[1][2].

In Vitro

β-Cembrenediol (25, 50, 100, 200 µg/mL) shows inhibition on lettuce seedling stem length and root length in a dose-dependent manner[1].
β-Cembrenediol (0, 0.2, 0.5, 1, 5, 10 µM) reduces the migration and colony formation in a dose-dependent manner[2].
β-Cembrenediol (5, 10, 20 µM; 48 h) decreases the protein expression of TDO2, IDO1 in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Cembrenediol Related Antibodies

Western Blot Analysis[2]

Cell Line: PC-3M cells
Concentration: 5, 10, 20 µM
Incubation Time: 48 h
Result: Decreased the protein expression of TDO2, IDO1 in a dose-dependent manner.
In Vivo

β-Cembrenediol (15 mg/kg; p.o.; daily for 8 weeks) shows anti-tumor activity in prostate cancer mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nude mice (PC-3M PC cells)[2]
Dosage: 15 mg/kg
Administration: P.o.; daily for 8 weeks
Result: Significantly suppressed the development, extended the latency, and delayed the onset of the locoregional PC-3M cell tumor recurrence, reduced mice plasma total prostate-specific antigen and plasma kynurenine level.
Molecular Weight

306.48

Formula

C20H34O2
CAS No.
SMILES

O[C@]1(C)C[C@@H](O)/C=C(C)/CC/C=C(C)/CC[C@@H](C(C)C)/C=C/1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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β-Cembrenediol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Cembrenediol57605-81-9Othersorally activePC-3M cellsTDO2IDO1prostate cancerInhibitorinhibitorinhibit

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