1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Calcium Channel
  3. Verticilide

Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9?μM)).

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Verticilide Chemical Structure

Verticilide Chemical Structure

CAS No. : 693778-57-3

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Description

Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9?μM))[1].

Molecular Weight

853.09

Formula

C44H76N4O12

CAS No.
Sequence

cyclo[N(Me)Ala-D-ONle(Me)-N(Me)Ala-D-ONle(Me)-N(Me)Ala-D-ONle(Me)-N(Me)Ala-D-ONle(Me)]

SMILES

CCCCC[C@@H](OC([C@@H](N(C([C@H](OC([C@@H](N(C1=O)C)C)=O)CCCCC)=O)C)C)=O)C(N([C@H](C(O[C@@H](C(N([C@H](C(O[C@@H]1CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O

Structure Classification
Initial Source

Verticillium sp. FKI-1033

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Verticilide
Cat. No.:
HY-N7491
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