2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. UK-66914

UK-66914, is a class III antiarrhythmic agent that specifically acts on the delayed rectifier potassium current (I_K). UK-66914 is designed to prolong action potential duration (APD) and increase cardiac refractory period, thereby potentially terminating the reentry mechanism in arrhythmias without affecting the serious side effects of antiarrhythmic drugs associated with other ion channels such as Na+ and Ca2+ currents.

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UK-66914 Chemical Structure

UK-66914 Chemical Structure

CAS No. : 113049-11-9

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Description

UK-66914, is a class III antiarrhythmic agent that specifically acts on the delayed rectifier potassium current (I_K). UK-66914 is designed to prolong action potential duration (APD) and increase cardiac refractory period, thereby potentially terminating the reentry mechanism in arrhythmias without affecting the serious side effects of antiarrhythmic drugs associated with other ion channels such as Na+ and Ca2+ currents[1].

Molecular Weight

376.47

Formula

C18H24N4O3S
CAS No.
SMILES

CS(=O)(NC1=CC=C(C=C1)C(CN2CCN(CC2)C3=CC=NC=C3)O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UK-66914 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK-66914113049-11-9UK66914UK 66914Potassium ChannelKcsAInhibitorinhibitorinhibit

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