Tolbutamide-d₉

Name: Tolbutamide-d 9
Brand: MedChemExpress
SKU: HY-B0401S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0401S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Tolbutamide-d₉ is the deuterium labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.

For research use only. We do not sell to patients.

Tolbutamide-d<sub>9</sub> Chemical Structure

Tolbutamide-d₉ Chemical Structure

CAS No. : 1219794-57-6

Size	Price	Stock	Quantity
1 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 730	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tolbutamide-d₉:

Tolbutamide In-stock
Tolbutamide sodium Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Tolbutamide-d₉ is the deuterium labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

279.40

Formula

C₁₂H₉D₉N₂O₃S

CAS No.

1219794-57-6

Unlabeled Cas

64-77-7

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(C)C=C1)(NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 30 mg/mL (107.37 mM)

DMF : ≥ 30 mg/mL (107.37 mM)

DMSO : ≥ 30 mg/mL (107.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol:PBS (pH 7.2) (1:1) : ≥ 0.14 mg/mL (0.50 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5791 mL	17.8955 mL	35.7910 mL
5 mM	0.7158 mL	3.5791 mL	7.1582 mL
10 mM	0.3579 mL	1.7895 mL	3.5791 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Wray, H.L. and A.W. Harris, Adenosine 3', 5'-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53(1): p. 291-4. [Content Brief]

[3]. Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54(2): p. 125-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMF / DMSO	1 mM	3.5791 mL	17.8955 mL	35.7910 mL	89.4775 mL
	5 mM	0.7158 mL	3.5791 mL	7.1582 mL	17.8955 mL
	10 mM	0.3579 mL	1.7895 mL	3.5791 mL	8.9477 mL
	15 mM	0.2386 mL	1.1930 mL	2.3861 mL	5.9652 mL
	20 mM	0.1790 mL	0.8948 mL	1.7895 mL	4.4739 mL
	25 mM	0.1432 mL	0.7158 mL	1.4316 mL	3.5791 mL
	30 mM	0.1193 mL	0.5965 mL	1.1930 mL	2.9826 mL
	40 mM	0.0895 mL	0.4474 mL	0.8948 mL	2.2369 mL
	50 mM	0.0716 mL	0.3579 mL	0.7158 mL	1.7895 mL
	60 mM	0.0597 mL	0.2983 mL	0.5965 mL	1.4913 mL
	80 mM	0.0447 mL	0.2237 mL	0.4474 mL	1.1185 mL
	100 mM	0.0358 mL	0.1790 mL	0.3579 mL	0.8948 mL