Tetrapeptide-30 

Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation^[1].

Tetrapeptide-30 (0-10 μg/mL, 24 h) can effectively reduce UVB-induced gene expression of IL-6, TNF-α and POMC (proopiomelanocorticotropin), and also decreased IL-8 gene expression in a dose-dependent manner^[1].
Tetrapeptide-30 (PKEK) is highly hydrophilic and has good skin penetration in microemulsion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

500.59

C₂₂H₄₀N₆O₇

1036207-61-0

Solid

White to off-white

PKEK

NCCCC[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@@H]1CCCN1)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Alessandra Marini, et al. Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects. Exp Dermatol. 2012 Feb;21(2):140-6.  [Content Brief]

  [2]. Reinhard H H Neubert, et al. Dermal peptide delivery using enhancer moleculs and colloidal carrier systems. Part II: Tetrapeptide PKEK. Eur J Pharm Biopharm. 2018 Mar;124:28-33.  [Content Brief]