2. Stem Cell/Wnt
  3. YAP
  4. TEAD-IN-11

TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM). TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research.

For research use only. We do not sell to patients.

TEAD-IN-11 Chemical Structure

TEAD-IN-11 Chemical Structure

CAS No. : 3032196-88-3

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TEAD-IN-11 Related Antibodies

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Description

TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM). TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research[1].

IC50 & Target

TEAD1

8.7 nM (IC50)

TEAD2

3.4 nM (IC50)

TEAD3

5.6 nM (IC50)

In Vitro

TEAD-IN-11 has a great inhibition for MCF-7 reporter assay (IC50≤10 nM)[1].
TEAD-IN-11 has a great selectivity for TEAD1 and TEAD2 with 93% and 95% inhibition in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TEAD-IN-11 Related Antibodies

Cell Viability Assay[1]

Cell Line: NCl-H226 and H2052 cell lines
Concentration:
Incubation Time: 6 days
Result: The inhibitory effect of H2052 cell line (IC50≤100 nM) as well as that of NCl-H226 cell line (IC50:≤100 nM).

Cell Proliferation Assay[1]

Cell Line: NCl-H226 and H2052 cell lines
Concentration:
Incubation Time: 7 days
Result: The inhibition rate of anti-proliferation of both cell lines was greater than 75%.
Molecular Weight

293.28

Formula

C16H14F3NO
CAS No.
SMILES

FC(F)(F)C1=CC=C(C#CC2CN(C(C=C)=O)CC2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TEAD-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TEAD-IN-113032196-88-3YAPYes-associated proteinTEADcovalent inhibitordrughunterNCl-H226 and H2052 cell linesInhibitorinhibitorinhibit

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