2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor
  4. SUN-1334H free base

SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC50 of 20.3 nM and Ki of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC50 of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs.

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SUN-1334H free base Chemical Structure

SUN-1334H free base Chemical Structure

CAS No. : 607737-00-8

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SUN-1334H free base Related Antibodies

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Description

SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC50 of 20.3 nM and Ki of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC50 of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs[1].

IC50 & Target

H1 Receptor

20.3 nM (IC50)

Dopamine D3 receptor

3.43 μM (IC50)

σ1

5.46 μM (IC50)

Alpha-1D adrenergic receptor

7.76 μM (IC50)

Molecular Weight

416.46

Formula

C23H26F2N2O3
CAS No.
SMILES

OC(COC/C=C/CN(CC1)CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SUN-1334H free base Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SUN-1334H607737-00-8Histamine ReceptorDopamine ReceptorAdrenergic ReceptorSigma ReceptorBeta ReceptorOrally activeguinea pigSprague-Dawley ratCD-1 mousebeagle dogrhinitisInhibitorinhibitorinhibit

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