voltage sensitive

By Targets:	Autophagy (2) Calcium Channel (14) Carbonic Anhydrase (3) Fluorescent Dye (9) GABA Receptor (3) HDAC (2) iGluR (3) Isotope-Labeled Compounds (2) Mitophagy (2) Parasite (1) Potassium Channel (5) PROTAC Linkers (1) Sodium Channel (16)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (4) Neurological Disease (20)

Targets Recommended: VDAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1427

Di-2-ANEPEQ	Fluorescent Dye	Neurological Disease
Di-2-ANEPEQ is a voltage sensitive membrane potential fluorescence dye. Di-2-ANEPEQ can be used for the evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system .

HY-D1512

Oxonol 595

Fluorescent Dye Others

Oxonol 595 is a voltage-sensitive fluorescent dye .
HY-P5821

ω-Conotoxin CVIA

Calcium Channel Neurological Disease

ω-Conotoxin CVIA, a 27 amino acid neuropeptide toxin, is an voltage sensitive calcium channels blocker .
HY-U00218

McN5691

RWJ26240
Calcium Channel Cardiovascular Disease

McN5691 is a voltage-sensitive calcium channel blocker.
HY-D1439

RH 795

Fluorescent Dye Others

RH 795 is a fast-response voltage-sensitive dye .
HY-N12093

Cevadine

Sodium Channel Parasite Infection

Cevadine is a voltage-sensitive sodium channel agonist. Cevadine has insecticidal activity .
HY-111157

Dezinamide

AHR11748; AN051; ADD94057
Sodium Channel Neurological Disease

Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .

Oxonol 595	Fluorescent Dye	Others
Oxonol 595 is a voltage-sensitive fluorescent dye .

ω-Conotoxin CVIA	Calcium Channel	Neurological Disease
ω-Conotoxin CVIA, a 27 amino acid neuropeptide toxin, is an voltage sensitive calcium channels blocker .

McN5691 RWJ26240	Calcium Channel	Cardiovascular Disease
McN5691 is a voltage-sensitive calcium channel blocker.

RH 795	Fluorescent Dye	Others
RH 795 is a fast-response voltage-sensitive dye .

Cevadine	Sodium Channel Parasite	Infection
Cevadine is a voltage-sensitive sodium channel agonist. Cevadine has insecticidal activity .

Dezinamide AHR11748; AN051; ADD94057	Sodium Channel	Neurological Disease
Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .

HY-P5868

mHuwentoxin-IV	Sodium Channel	Neurological Disease
mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC₅₀ of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .

HY-101892

DiBAC4(3)

5+ Cited Publications

Fluorescent Dye Others

DiBAC4(3) is a voltage-sensitive fluorescent dye (λ_ex=490 nm, λ_em=505 nm).

DiBAC4(3) 5+ Cited Publications	Fluorescent Dye	Others
DiBAC4(3) is a voltage-sensitive fluorescent dye (λ_ex=490 nm, λ_em=505 nm).

HY-N3990

Hardwickiic acid 1 Publications Verification (-)-Hardwikiic acid	Sodium Channel	Infection Neurological Disease
Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity .

HY-P10025

ω-Conotoxin CVID

Leconotide; AM336; CNSB004
Calcium Channel Neurological Disease

ω-Conotoxin CVID (Leconotide, AM336, CNSB004) blocks neuronal voltage sensitive calcium channel .

ω-Conotoxin CVID Leconotide; AM336; CNSB004	Calcium Channel	Neurological Disease
ω-Conotoxin CVID (Leconotide, AM336, CNSB004) blocks neuronal voltage sensitive calcium channel .

HY-103318

PD173212 1 Publications Verification	Calcium Channel	Neurological Disease
PD173212 is a selective *N-type voltage* sensitive calcium channel (VSCC) blocker, with an IC₅₀** of 36 nM in IMR-32 assays.

HY-101891

Di-8-ANEPPS

Fluorescent Dye Others

Di-8-ANEPPS is a naphthylstyryl voltage-sensitive dye, shifting both their fluorescence excitation and emission spectra upon changes in V_m .
HY-114958

RH 421

Fluorescent Dye Others

RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .

Di-8-ANEPPS	Fluorescent Dye	Others
Di-8-ANEPPS is a naphthylstyryl voltage-sensitive dye, shifting both their fluorescence excitation and emission spectra upon changes in V_m .

RH 421	Fluorescent Dye	Others
RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .

HY-D1092

DiBAC4(5)	Fluorescent Dye	Neurological Disease
DiBaC4(5) is a fluorescent voltage-sensitive dye that can be used to monitor the transmembrane potentials when Papain-dissociated retinal cells from adult zebrafish were exposed to GABAergic ligands. DiBaC4(5) is a potential-sensitive fluorescence dye .

HY-W042039

Methyl homoveratrate	Calcium Channel	Cardiovascular Disease
Methyl homoveratrate, a metabolite of RWJ-26240 in vivo, can be identified in plasma, urine and faecal extract. McN5691 (RWJ-26240) is a voltage-sensitive calcium channel blocker .

HY-P5143

ω-Conotoxin SO3	Calcium Channel	Inflammation/Immunology
ω-Conotoxin SO3 is a blocker of N-type voltage-sensitive calcium channel. ω-Conotoxin SO3 is an analgesicω-conotoxin that can be isolated from the venom of C. striatus .

HY-P5184

Hainantoxin-IV HNTX-IV	Sodium Channel	Neurological Disease
Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .

HY-12650S1

Mirogabalin-d4 DS5565-d₄	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Mirogabalin-d₄ (DS5565-d₄) is a deuterated compound of Mirogabalin (HY-12650), a ligand that selectively targets the voltage-sensitive calcium channel complex α2δ-1 .

HY-B0246

Carbamazepine Maximum Cited Publications 10 Publications Verification CBZ; NSC 169864	Sodium Channel Autophagy Mitophagy Potassium Channel Calcium Channel HDAC	Neurological Disease Cancer
Carbamazepine is an orally active *pressure-sensitive* sodium ion channel blocker with an IC₅₀** of 131 μM. Carbamazepine blocks voltage gated Na ⁺, Ca ²⁺, and K ⁺ channels, and is also a HDAC inhibitor (IC₅₀: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain .

HY-12650

Mirogabalin 4 Publications Verification DS5565	Calcium Channel	Neurological Disease
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.

HY-B0122

Topiramate 4 Publications Verification McN 4853; RWJ 17021	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-B0122A

Topiramate lithium McN 4853 lithium; RWJ 17021 lithium	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-12545

Brevetoxin-3 PbTx-3	Sodium Channel	Inflammation/Immunology
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺ channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

HY-108425A

AMG8380	Sodium Channel	Neurological Disease
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC₅₀s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC₅₀ of 2560 nM .

HY-P5771

Jingzhaotoxin-IX	Sodium Channel	Neurological Disease
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .

HY-110234

Topiramate D12 McN 4853 D12 ; RWJ 17021 D12	iGluR GABA Receptor Sodium Channel Calcium Channel Potassium Channel Carbonic Anhydrase	Neurological Disease
Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .

HY-12650R

Mirogabalin (Standard)	Calcium Channel	Neurological Disease
Mirogabalin (Standard) is the analytical standard of Mirogabalin. This product is intended for research and analytical applications. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.

HY-B0246R

Carbamazepine (Standard)	Sodium Channel Autophagy Mitophagy Potassium Channel Calcium Channel HDAC	Neurological Disease Cancer
Carbamazepine (Standard) is the analytical standard of Carbamazepine. This product is intended for research and analytical applications. Carbamazepine is an orally active *pressure-sensitive* sodium ion channel blocker with an IC₅₀** of 131 μM. Carbamazepine blocks voltage gated Na ⁺, Ca ²⁺, and K ⁺ channels, and is also a HDAC inhibitor (IC₅₀: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain .

HY-110358

QAQ dichloride	Sodium Channel	Inflammation/Immunology
QAQ dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-108425

AMG8379	Sodium Channel	Neurological Disease
AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC₅₀s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC₅₀ of 3.1 nM .

HY-110358A

QAQ	Sodium Channel	Inflammation/Immunology
QAQ dichloride dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-125452

DiSBAC10	Fluorescent Dye	Others
DiSBAC10 is a voltage-sensitive fluorescent probe used to study cell membrane electrical activity in FRET assays. In a resting polarized cell, DiSBAC10 resides on the outer leaflet of the membrane where it accepts photons from excited fluorescein-labeled proteins and re-emits the photons at a higher wavelength. Depolarization of the cell causes rapid translocation of DiSBAC10 to the inner leaflet of the membrane, thereby increasing the distance between fluorophores and reducing the FRET signal.

HY-140677

mPEG-amine (MW 5000) mPEG-NH2 (MW 5000)	PROTAC Linkers	Cancer
mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies .

HY-12650S

Mirogabalin-13C2,d1 (Mixture of Diastereomers) DS5565-¹³C₂,d₁ (Mixture of Diastereomers)	Isotope-Labeled Compounds	Others
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .

HY-129763

Di-4-ANEPPS	Fluorescent Dye	Others
Di-4-ANEPPS is a voltage-sensitive dye in membrane potential. Di-4-ANEPPS allows reaching a time resolution better than 1 ms and exhibits changes in fluorescence of up to 10% per 100 mV. Di-4-ANEPPS is a common tool for mapping cardiac electrical activity. Di-4-ANEPPS demonstrate significant direct irreversible effect on spontaneous heart rate and ventricular impulse conduction in rabbit isolated heart model .

Cat. No.	Product Name

HY-L118

Sodium Channel Blocker Library	130 compounds
Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion. MCE offers a unique collection of 130 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Sodium Channel Blocker Library

130 compounds

Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion.

MCE offers a unique collection of 130 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Cat. No.	Product Name	Type

HY-D1427

Di-2-ANEPEQ	Fluorescent Dyes/Probes
Di-2-ANEPEQ is a voltage sensitive membrane potential fluorescence dye. Di-2-ANEPEQ can be used for the evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system .

HY-D1512

Oxonol 595

Fluorescent Dyes/Probes

Oxonol 595 is a voltage-sensitive fluorescent dye .
HY-101892

DiBAC4(3)

5+ Cited Publications

Fluorescent Dyes/Probes

DiBAC4(3) is a voltage-sensitive fluorescent dye (λ_ex=490 nm, λ_em=505 nm).
HY-101891

Di-8-ANEPPS

Fluorescent Dyes/Probes

Di-8-ANEPPS is a naphthylstyryl voltage-sensitive dye, shifting both their fluorescence excitation and emission spectra upon changes in V_m .
HY-114958

RH 421

Fluorescent Dyes/Probes

RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .

Oxonol 595	Fluorescent Dyes/Probes
Oxonol 595 is a voltage-sensitive fluorescent dye .

DiBAC4(3) 5+ Cited Publications	Fluorescent Dyes/Probes
DiBAC4(3) is a voltage-sensitive fluorescent dye (λ_ex=490 nm, λ_em=505 nm).

Di-8-ANEPPS	Fluorescent Dyes/Probes
Di-8-ANEPPS is a naphthylstyryl voltage-sensitive dye, shifting both their fluorescence excitation and emission spectra upon changes in V_m .

RH 421	Fluorescent Dyes/Probes
RH 421 is a voltage-sensitive styryl dye that can penetrate through the lipid bilayers. RH 421 is a chromogenic substrate for β-galactosidase .

HY-D1092

DiBAC4(5)	Fluorescent Dyes/Probes
DiBaC4(5) is a fluorescent voltage-sensitive dye that can be used to monitor the transmembrane potentials when Papain-dissociated retinal cells from adult zebrafish were exposed to GABAergic ligands. DiBaC4(5) is a potential-sensitive fluorescence dye .

HY-125452

DiSBAC10	Fluorescent Dyes/Probes
DiSBAC10 is a voltage-sensitive fluorescent probe used to study cell membrane electrical activity in FRET assays. In a resting polarized cell, DiSBAC10 resides on the outer leaflet of the membrane where it accepts photons from excited fluorescein-labeled proteins and re-emits the photons at a higher wavelength. Depolarization of the cell causes rapid translocation of DiSBAC10 to the inner leaflet of the membrane, thereby increasing the distance between fluorophores and reducing the FRET signal.

DiSBAC10

Fluorescent Dyes/Probes

DiSBAC10 is a voltage-sensitive fluorescent probe used to study cell membrane electrical activity in FRET assays. In a resting polarized cell, DiSBAC10 resides on the outer leaflet of the membrane where it accepts photons from excited fluorescein-labeled proteins and re-emits the photons at a higher wavelength. Depolarization of the cell causes rapid translocation of DiSBAC10 to the inner leaflet of the membrane, thereby increasing the distance between fluorophores and reducing the FRET signal.

HY-129763

Di-4-ANEPPS

Dyes

Di-4-ANEPPS is a voltage-sensitive dye in membrane potential. Di-4-ANEPPS allows reaching a time resolution better than 1 ms and exhibits changes in fluorescence of up to 10% per 100 mV. Di-4-ANEPPS is a common tool for mapping cardiac electrical activity. Di-4-ANEPPS demonstrate significant direct irreversible effect on spontaneous heart rate and ventricular impulse conduction in rabbit isolated heart model .

Cat. No.	Product Name	Type

HY-140677

mPEG-amine (MW 5000)

mPEG-NH2 (MW 5000)

Drug Delivery

mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies .

HY-111157

Dezinamide

AHR11748; AN051; ADD94057
Cell Assay Reagents

Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .

Cat. No.	Product Name	Target	Research Area

HY-P5821

ω-Conotoxin CVIA

Calcium Channel Neurological Disease

ω-Conotoxin CVIA, a 27 amino acid neuropeptide toxin, is an voltage sensitive calcium channels blocker .

HY-P5868

mHuwentoxin-IV	Sodium Channel	Neurological Disease
mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC₅₀ of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .

HY-P10025

ω-Conotoxin CVID

Leconotide; AM336; CNSB004
Calcium Channel Neurological Disease

ω-Conotoxin CVID (Leconotide, AM336, CNSB004) blocks neuronal voltage sensitive calcium channel .

HY-P5143

ω-Conotoxin SO3	Calcium Channel	Inflammation/Immunology
ω-Conotoxin SO3 is a blocker of N-type voltage-sensitive calcium channel. ω-Conotoxin SO3 is an analgesicω-conotoxin that can be isolated from the venom of C. striatus .

HY-P5184

Hainantoxin-IV HNTX-IV	Sodium Channel	Neurological Disease
Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .

HY-P5771

Jingzhaotoxin-IX	Sodium Channel	Neurological Disease
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3990

Hardwickiic acid 1 Publications Verification (-)-Hardwikiic acid	Classification of Application Fields Neurological Disease Pueraria tuberosa (Roxb. ex Willd.) DC. Source classification Plants Compositae Infection other families Terpenoids Croton tiglium Linn. Diterpenoids Euphorbiaceae Disease Research Fields	Sodium Channel
Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity .

HY-N12093

Cevadine	Structural Classification Alkaloids Other Alkaloids Source classification Veratrum oblongum Loes. Plants Melanthiaceae	Sodium Channel Parasite
Cevadine is a voltage-sensitive sodium channel agonist. Cevadine has insecticidal activity .

HY-12545

Brevetoxin-3 PbTx-3	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology	Sodium Channel
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺ channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

Cat. No.	Compare	Product Name	Species	Source

HY-P72109

	CACNA2D1 Protein, Human (His-SUMO) CA2D1_HUMAN; CACN A2; CACNA2; Cacna2d1; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; L type calcium channel subunit alpha 2; MHS 3; MHS3; voltage dependent calcium channel subunit alpha 2/delta 1; voltage gated calcium channel subunit alpha 2/delta 1; voltage-dependent calcium channel subunit delta-1; voltage-gated calcium channel subunit alpha-2/delta-1	Human	E. coli
	The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CACNA2D1 Protein, Human (His-SUMO) is 141 a.a., with molecular weight of ~32.3 kDa.

Cat. No.	Product Name	Chemical Structure

HY-12650S1

Mirogabalin-d4

Mirogabalin-d₄ (DS5565-d₄) is a deuterated compound of Mirogabalin (HY-12650), a ligand that selectively targets the voltage-sensitive calcium channel complex α2δ-1 .

HY-12650S

Mirogabalin-13C2,d1 (Mixture of Diastereomers)
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .


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