diketopiperazine

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Bacterial (2) Drug Metabolite (1) Endogenous Metabolite (4) NF-κB (2) Parasite (1)
By Research Areas:	Cardiovascular Disease (1) Infection (9) Inflammation/Immunology (4) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107091

Aspartyl-alanyl-diketopiperazine DA-DKP	Others	Inflammation/Immunology
Aspartyl-alanyl-diketopiperazine (DA-DKP) is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin and can modulate the inflammatory immune response through a molecular pathway implicated in T- lymphocyte anergy .

HY-N12900

TDD

Tryptophandehydrobutyrine diketopiperazine
Others Others

TDD (Tryptophandehydrobutyrine diketopiperazine) is a mold metabolite and can be isolated from Streptomyces spectabilis .
HY-114547

PD 109488

Quinapril diketopiperazine
Others Others

PD 109488 is a quinapril diketopiperazine metabolite .
HY-N10222

Roquefortine E

Others Infection

Roquefortine E is a diketopiperazine from an Australian isolate of Gymnoascus reessii .
HY-N8548

Fellutanine A

Endogenous Metabolite Infection

Fellutanine A, a diketopiperazine alkaloid, is a fungal metabolite from cultures of Penicillium fellutanum .

TDD Tryptophandehydrobutyrine diketopiperazine	Others	Others
TDD (Tryptophandehydrobutyrine diketopiperazine) is a mold metabolite and can be isolated from Streptomyces spectabilis .

PD 109488 Quinapril diketopiperazine	Others	Others
PD 109488 is a quinapril diketopiperazine metabolite .

Roquefortine E	Others	Infection
Roquefortine E is a diketopiperazine from an Australian isolate of Gymnoascus reessii .

Fellutanine A	Endogenous Metabolite	Infection
Fellutanine A, a diketopiperazine alkaloid, is a fungal metabolite from cultures of Penicillium fellutanum .

HY-N8513

Brevicompanine B	Parasite	Infection
Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC₅₀ of 35 mg/mL .

HY-117713

Cycloechinulin

Endogenous Metabolite Others

Cycloechinulin is a diketopiperazine fungal metabolite .
HY-118100

Cyclo(Tyr-Val)

Cyclo(L-Tyr-L-Val)
Drug Metabolite Others

Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.

Cycloechinulin	Endogenous Metabolite	Others
Cycloechinulin is a diketopiperazine fungal metabolite .

Cyclo(Tyr-Val) Cyclo(L-Tyr-L-Val)	Drug Metabolite	Others
Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.

HY-P1938

Cyclo(L-Pro-L-Val)	Bacterial	Infection
Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide .

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-121548

Drimentine A	Others	Infection
Drimentine A is a terpenylated diketopiperazine originally isolated from Actinomycete bacteria.nlike Drimentine B and Drimentine C, Drimentine A does not have anticancer activity.

HY-120190

Citreoindole	Others	Infection
Citreoindole is a diketopiperazine metabolite isolated from a hybrid cell fusion of two strains of P. citreovirde that is cytotoxic in vitro against HeLa cells at 8.4 μM.

HY-113702

PD 113413	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
PD 113413 is formed by subsequent hydrolysis of the diketopiperazine quinapril analog. PD 113413 is a potent angiotensin-converting enzyme inhibitor. PD 113413 can be used for research of hypertension and congestive heart failure .

HY-101402A

Cyclo(his-pro) TFA Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA	NF-κB Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-142075

Antibacterial agent 134	Bacterial	Infection
Antibacterial agent 134 (compound 1) is an diketopiperazine alkaloid with antimicrobial activity. Antibacterial agent 134 is the major metabolite in the culture of Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1 .

HY-125092

Drimentine C	Others	Infection
Drimentine C is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 63 and 98% in vitro when used at concentrations of 12.5 and 100 μg/mL, respectively.

HY-118079

Drimentine B	Others	Infection
Drimentine B is a terpenylated diketopiperazine originally isolated from Actinomycete bacteria that has anticancer activity. It inhibits the proliferation of NS-1 murine β lymphocyte myeloma cells by 41 and 59% in vitro when used at concentrations of 50 and 100 μg/mL, respectively.

Cat. No.	Product Name	Target	Research Area

HY-P1938

Cyclo(L-Pro-L-Val)	Bacterial	Infection
Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide .

HY-P3472

Cyclo(IP) Cyclo(L-Pro-L-Ile)	Peptides	Inflammation/Immunology
Cyclo(IP) (Cyclo-(L-Pro-L-Ile)), a Diketopiperazine can be derived From Bacillus thuringiensis JCK-1233, results in suppression of PWD severity and increased the expression of defense-related genes similarly to Bacillus thuringiensis JCK-1233 treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12900

TDD Tryptophandehydrobutyrine diketopiperazine	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Others
TDD (Tryptophandehydrobutyrine diketopiperazine) is a mold metabolite and can be isolated from Streptomyces spectabilis .

HY-N10222

Roquefortine E	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Others
Roquefortine E is a diketopiperazine from an Australian isolate of Gymnoascus reessii .

HY-N8548

Fellutanine A	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Endogenous Metabolite
Fellutanine A, a diketopiperazine alkaloid, is a fungal metabolite from cultures of Penicillium fellutanum .

HY-N8513

Brevicompanine B	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC₅₀ of 35 mg/mL .

HY-117713

Cycloechinulin	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Indole Alkaloids	Endogenous Metabolite
Cycloechinulin is a diketopiperazine fungal metabolite .

HY-P1938

Cyclo(L-Pro-L-Val)	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide .

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	Structural Classification Natural Products Source classification Endogenous metabolite	NF-κB Endogenous Metabolite
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-101402A

Cyclo(his-pro) TFA Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA	Natural Products Source classification Endogenous metabolite	NF-κB Endogenous Metabolite
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-142075

Antibacterial agent 134	Structural Classification Alkaloids Microorganisms Source classification	Bacterial
Antibacterial agent 134 (compound 1) is an diketopiperazine alkaloid with antimicrobial activity. Antibacterial agent 134 is the major metabolite in the culture of Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1 .

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