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chirality

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50

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2

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8

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1

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6

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2

Isotope-Labeled Compounds

2

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W002502
    (DHQ)2PHAL

    Hydroquinine 1,4-phthalazinediyl diether; 1,4-Bis(dihydroquinine)phthalazine; (DHQ)2PHAL

    		 Biochemical Assay Reagents Others
    (DHQ)2PHAL (Hydroquinine 1,4-phthalazinediyl diether; 1,4-Bis(dihydroquinine)phthalazine) can be utilized as chiral ligand in asymmetric dihydroxylation .
    (DHQ)2PHAL
  • HY-I0259
    8-Amino-2-naphthol

    		Biochemical Assay Reagents Others
    8-Amino-2-naphthol is a photoactive charge transfer compounds, which can be used as fluorescent probe. 8-Amino-2-naphthol is also utilized as chiral organocatalyst .
    8-Amino-2-naphthol
  • HY-10193A
    (1R)-AZD-1480

    		JAK Cancer
    (1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor .
    (1R)-AZD-1480
  • HY-W098280
    Phenylglycine methyl ester

    		Biochemical Assay Reagents Others
    Phenylglycine methyl ester is a chiral anisotropic reagent. Phenylglycine methyl ester can be used for absolute configuration determination of various chiral carboxylic acids .
    Phenylglycine methyl ester
  • HY-116653
    Flurtamone

    		Stearoyl-CoA Desaturase (SCD) Others
    Flurtamone is a chiral herbicide with acute toxicity levels to Selenastrum capricornutum .
    Flurtamone
  • HY-136369
    Ethofumesate

    		Others Others
    Ethofumesate, a chiral herbicide, acts by inhibiting mitosis and reducing photosynthesis and plant respiration .
    Ethofumesate
  • HY-Y1126
    (2S)-2-Pyrrolidinemethanol

    (S)-(+)-Prolinol; (S)-(+)-Pyrrolidin-2-ylmethanol; (S)-1-(Pyrrolidin-2-yl)methanol

    		 Biochemical Assay Reagents Others
    (2S)-2-Pyrrolidinemethanol ((S)-(+)-Prolinol; (S)-(+)-Pyrrolidin-2-ylmethanol; (S)-1-(Pyrrolidin-2-yl)methanol) reveals binucleophilic character and can be anchored to phthalonitrile derivative from both nitrogen and oxygen atoms. (2S)-2-Pyrrolidinemethanol can be utilized as chiral catalyst .
    (2S)-2-Pyrrolidinemethanol
  • HY-B1871
    Metolachlor

    		Others Others
    Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers .
    Metolachlor
  • HY-N9022
    (S)-1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone

    		Others Others
    (S)-1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone is an enantiopure chiral alcohol. Stereoselective reduction of prochiral ketones is studied by using both cell cultures and wild tissues of various endemic plant species .
    (S)-1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone
  • HY-123622
    CYMAL-5

    		Biochemical Assay Reagents Others
    CYMAL-5 is a cycloalkyl aliphatic saccharide. CYMAL-5 is a glycosidic surfactant (GS) with a chiral maltose polar head group and a cyclohexyl-pentyl hydrophobic tail. CYMAL-5 is a non-ionic detergent that has a tenfold lower critical micelle concentration (CMC) in comparison with OG, and has previously been used for membrane protein extraction or crystallization of membrane proteins for X-ray crystallographic studies .
    CYMAL-5
  • HY-125630
    Decacyclene

    		Others Others
    Decacyclene is a large polycyclic aromatic hydrocarbon with a triple symmetry. Decacyclene is a three-blade molecular propeller in the solid state, and crystal structure analysis shows that the molecule has a non-planar twisted form, and the crystal is chiral, which may correspond to the enantiomers of the Decacyclene propeller. Decacyclene can be used for research in chemical synthesis and materials science .
    Decacyclene
  • HY-149727
    β2AR agonist 2

    		Adrenergic Receptor Metabolic Disease
    β2AR agonist 2(compound 8a) is a β2 -Adrenergic receptor (β2AR) agonist. β2AR agonist 2 is a saturated nitrogen ring compound containing 4- to 7-membered heterocycle. β2AR agonist 2 has a chiral structure (the -R form) by carrying carbon containing the essential hydroxyl, thereby enhancing cellular glucose uptake (GU) activity and significantly stimulating glucose uptake by skeletal muscle cells. β2AR agonist 2 can be used in the study of Type 2 Diabetes (T2D) .
    β2AR agonist 2
  • HY-14507
    YK-4-279
    5+ Cited Publications

    		 DNA/RNA Synthesis Apoptosis Cancer
    YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer .
    YK-4-279
  • HY-114769
    Beflubutamid

    UBH 820

    		 Others Others
    Beflubutamid is a chiral soil herbicide against dicotyledonous weeds in cereals .
    Beflubutamid
  • HY-W062695
    (R)-Acalabrutinib

    (R)-ACP-196

    		 Btk Cancer
    (R)-Acalabrutinib ((R)-ACP-196) is the enantiomer of Acalabrutinib (HY-17600). (R)-Acalabrutinib is an inhibitor for Bruton’s tyrosine kinase (BTK) .
    (R)-Acalabrutinib
  • HY-Y1080
    N-Acetyl-R-leucine

    N-Acetyl-D-leucine

    		 Amino Acid Derivatives Others
    N-Acetyl-R-leucine is an amino protecting group N-substituted chiral amino acid .
    N-Acetyl-R-leucine
  • HY-N9761
    Murrayanine

    		Others Others
    Murrayanine is a dimeric pyranoquinoline alkaloid, a mixture of two enantiomers with a predominant configuration on the chiral axis .
    Murrayanine
  • HY-40135
    L-Hydroxyproline

    (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid

    		 Endogenous Metabolite Others
    L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
    L-Hydroxyproline
  • HY-139166
    N-Palmitoyl-L-aspartate

    N-Palmitoyl aspartic acid

    		 Others Others
    N-Palmitoyl-L-aspartate (N-Palmitoyl aspartic acid) is a chiral compound with properties of the aggregates formed in aqueous solution .
    N-Palmitoyl-L-aspartate
  • HY-W017206
    1-Phenyl-2-nitropropene

    		Others Others
    1-Phenyl-2-nitropropene is the reduction product of acetophenone and can be used to prepare chiral amine compounds .
    1-Phenyl-2-nitropropene
  • HY-70027
    p53 and MDM2 proteins-interaction-inhibitor (chiral)

    		MDM-2/p53 E1/E2/E3 Enzyme Cancer
    p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins.
    p53 and MDM2 proteins-interaction-inhibitor (<em>chiral</em>)
  • HY-151702
    (2S)-N3-IsoSer

    		ADC Linker Others
    (2S)-N3-IsoSer is a click chemistry reagent, a chiral alpha-hydroxypropinoic acid, containing azide group.
    (2S)-N3-IsoSer
  • HY-151702A
    (2S)-N3-IsoSer (DCHA)

    		ADC Linker Others
    (2S)-N3-IsoSer DCHA is a click chemistry reagent, a chiral alpha-hydroxypropinoic acid, containing azide group .
    (2S)-N3-IsoSer (DCHA)
  • HY-40135S
    L-Hydroxyproline-d3

    		Isotope-Labeled Compounds Endogenous Metabolite Others
    L-Hydroxyproline-d3 is the deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
    L-Hydroxyproline-d3
  • HY-111487
    α-Methylacyl-CoA racemase 1

    		Others Metabolic Disease Cancer
    α-methylacyl-CoA racemase 1 is an enzyme that catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, and used as a maker in prostate and other cancer.
    α-Methylacyl-CoA racemase 1
  • HY-103028A
    GSK963
    1 Publications Verification

    		 RIP kinase Others
    GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro .
    GSK963
  • HY-120460
    8(R)-HETE

    8(R)-Hydroxyeicosatetraenoic acid

    		 Others Inflammation/Immunology
    8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
    8(R)-HETE
  • HY-161249
    Vanin-1-IN-4

    		Others Inflammation/Immunology
    Vanin-1-IN-4 (compound (S)-1) is vanin-1 inhibitor with a chiral methyl substituent, with profils as potent drug-candidate but exist as an amorphous solid .
    Vanin-1-IN-4
  • HY-117089
    Tetraconazole

    		Fungal Infection
    Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields . Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds .
    Tetraconazole
  • HY-17520
    Penthiopyrad

    MTF-753

    		 Fungal Infection
    Penthiopyrad (MTF-753) is a chiral carboxamide antifungal agent with a broad spectrum of fungicidal activity. Penthiopyrad can be used for controlling foliar and soil-borne plants diseases on a broad range of agricultural crops and turfgrass .
    Penthiopyrad
  • HY-W012618
    1-Phenyl-1-propanol

    		Others Others
    1-Phenyl-1-propanol is used as a chiral building block and synthetic intermediate in the pharmaceutical industries. 1-Phenyl-1-propanol is an intermediate of anti-depressant agent Fluoxetine .
    1-Phenyl-1-propanol
  • HY-117068
    (R)-Bromoenol lactone

    (R,E)-Bromoenol lactone

    		 Phospholipase Others
    (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM .
    (R)-Bromoenol lactone
  • HY-B1871S
    Metolachlor-d6

    		Isotope-Labeled Compounds Others
    Metolachlor-d6 is the deuterium labeled Metolachlor[1]. Metolachlor is a pre-emergent selective, chloroacetanilide herbicide for the control of a variety of annual grass and broad leaf weeds in corn and other crops. Metolachlor is a chiral herbicide consisting of four stereoisomers[2][3].
    Metolachlor-d6
  • HY-112792A
    (1S)-CCR2 antagonist 1

    		CCR Endocrinology
    (1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM .
    (1S)-CCR2 antagonist 1
  • HY-120986
    (S)-Bromoenol lactone

    (S)-BEL; (S,E)-Bromoenol lactone

    		 Phospholipase Inflammation/Immunology
    (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM .
    (S)-Bromoenol lactone
  • HY-115408
    9(R)-HETE

    9(R)-Hydroxyeicosatetraenoic acid

    		 Others Others
    9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.1 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
    9(R)-HETE
  • HY-123016
    9(S)-HODE cholesteryl ester

    		Endogenous Metabolite Cardiovascular Disease
    9(S)-HODE cholesteryl ester is originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation.2 9(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
    9(S)-HODE cholesteryl ester
  • HY-125394
    9(R)-HODE cholesteryl ester

    		Endogenous Metabolite Cardiovascular Disease
    9(R)-HODE cholesteryl ester is originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation.2 9(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
    9(R)-HODE cholesteryl ester
  • HY-120967A
    (2S)-OMPT

    		Biochemical Assay Reagents Others
    (2S)-OMPT triethylamine, a chiral oxirane derivative, is commonly used as a ligand in asymmetric catalysis, especially in the enantioselective synthesis of bioactive molecules such as amino acids and drugs. (2S)-OMPT triethylamine has unique chemical properties that allow it to selectively bind certain metal complexes and activate them in a way that favors the formation of specific enantiomers.
    (2S)-OMPT
  • HY-112653
    8(S)-HETE

    8(S)-Hydroxyeicosatetraenoic acid

    		 Others Inflammation/Immunology
    8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM.2 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM.3 Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
    8(S)-HETE
  • HY-75920
    Inhoffen Lythgoe diol

    		Biochemical Assay Reagents Others
    Inhoffen Lythgoe diol is an organic molecule commonly used in chiral selective reactions in organic synthesis. It can be used as a catalyst and a ligand, and has a wide range of applications in the preparation of nitrogen- and sulfur-containing natural products, pharmaceuticals, and material science. Inhoffen Lythgoe diol plays a very important role in the field of asymmetric synthesis. Although it has no direct medical application, it plays an important role in the production and research of many important chemicals.
    Inhoffen Lythgoe diol
  • HY-N0548
    α-Angelica lactone
    2 Publications Verification

    		 Glutathione S-transferase Cancer
    α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .
    α-Angelica lactone
  • HY-W010394
    Methyl 3-oxopentanoate

    		Biochemical Assay Reagents Others
    Methyl 3-oxopentanoate, which is also known as diethyl acetylmalonate or MEAM, Methyl 3-oxopentanoate is commonly used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and flavorings, and it can also Used as a reagent in organic chemical reactions, especially the formation of carbon-carbon bonds through malonate synthesis, the researchers also investigated the potential use of Methyl 3-oxopentanoate in the development of chiral auxiliaries that can aid in the selection of Controlling the stereochemistry of chemical reactions.
    Methyl 3-oxopentanoate
  • HY-W010507
    (R)-Methyl 3-hydroxybutanoate

    Methyl (R)-(-)-3-hydroxybutyrate

    		 Biochemical Assay Reagents Others
    (R)-Methyl 3-hydroxybutanoate, (R)-Methyl 3-hydroxybutanoate is an enantiomer, from the perspective of the methyl (-CH3) group, the hydroxyl (-OH) group on the third carbon atom The group faces to the right, a colorless transparent liquid, soluble in organic solvents such as ethanol and ether, insoluble in water, (R)-Methyl 3-hydroxybutanoate is usually used to synthesize various organic compounds (including drugs, agricultural chemicals and flavoring agents) It can also be used as a chiral auxiliary in asymmetric synthetic reactions involving the formation of chemical bonds in a stereoselective manner.
    (R)-Methyl 3-hydroxybutanoate
  • HY-F0003
    NADPH tetrasodium salt
    Maximum Cited Publications
    7 Publications Verification

    		 Ferroptosis Endogenous Metabolite Cancer
    NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis .
    NADPH tetrasodium salt
  • HY-W142618
    D-Glucal

    		Biochemical Assay Reagents Others
    D-Glucal is an organic compound belonging to the family of aldoses, which are monosaccharides containing an aldehyde functional group. It has a six-carbon structure and is derived from glucose by oxidation of the primary alcohol group at carbon 1 to an aldehyde group. D-Glucal is a white crystalline solid that is soluble in water and has a sweet taste. It is an important intermediate in the chemical synthesis of a wide variety of compounds, including pharmaceuticals, agrochemicals, and natural products. D-Glucal can be converted into other carbohydrate derivatives such as glycosides, glycoconjugates and amino sugars. It also plays a role in the study of carbohydrate chemistry, where it is used as a chiral building block for the synthesis of complex structures.
    D-Glucal
  • HY-17626B
    Alalevonadifloxacin hydrochloride

    WCK-2349 hydrochloride

    		 Antibiotic Infection
    Alalevonadifloxacin (hydrochloride) (WCK-2349 (hydrochloride)) is a oraaly active anti-methicillin-resistant Staphylococcus aureus (MRSA) antibiotic .
    Alalevonadifloxacin hydrochloride
  • HY-N12970
    14S(15R)-EET

    		Others Others
    14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .
    14S(15R)-EET
  • HY-10306
    Gantofiban

    		Integrin Cardiovascular Disease
    Gantofiban is a GPIIb/IIIa integrin receptor antagonist. By binding to this receptor, Gantofiban can effectively inhibit platelet aggregation, thereby exerting its antithrombotic effect .
    Gantofiban
  • HY-121814A
    (R)-Acenocoumarol

    (R)-Acenocoumarin; (R)-Nicoumalone

    		 Others Others
    (R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a short-acting oral anticoagulant that, like warfarin, works by inhibiting vitamin K epoxide reductase. In vitro evaluations have shown that (R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) has a higher intrinsic anticoagulant potency than warfarin and phenprocoumon. (R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) has a single chiral center that produces two different enantiomeric forms. (R)-(R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) has a longer plasma elimination half-life (6.6 hours) and a slower plasma clearance rate (1.9 L/hour) compared to the (S)-enantiomer (1.8 hours, 28.5 L/hour). (R)-(R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a more potent anticoagulant in vivo than the (S)-enantiomer.
    (R)-Acenocoumarol

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