Search Result

Isoforms Recommended:	Caspase 1

Results for "

caspase 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (46) Adenosine Receptor (1) AIM2 (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (10) Bacterial (1) Cathepsin (2) Cholinesterase (ChE) (1) COX (3) DNA/RNA Synthesis (1) Drug Metabolite (1) Fluorescent Dye (3) GPR55 (1) HIV (1) Influenza Virus (1) Integrin (2) Interleukin Related (10) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (1) NF-κB (1) NOD-like Receptor (NLR) (9) Pyroptosis (3) Reactive Oxygen Species (2) RIP kinase (1) SARS-CoV (1) Sodium Channel (1) TNF Receptor (2) Tyrosinase (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (38) Neurological Disease (7)

By Targets:

Caspase (46)

Adenosine Receptor (1)

AIM2 (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

Apoptosis (10)

Bacterial (1)

Cathepsin (2)

Cholinesterase (ChE) (1)

COX (3)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

Fluorescent Dye (3)

GPR55 (1)

HIV (1)

Influenza Virus (1)

Integrin (2)

Interleukin Related (10)

Isotope-Labeled Compounds (1)

Lactate Dehydrogenase (1)

NF-κB (1)

NOD-like Receptor (NLR) (9)

Pyroptosis (3)

Reactive Oxygen Species (2)

RIP kinase (1)

SARS-CoV (1)

Sodium Channel (1)

TNF Receptor (2)

Tyrosinase (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (23)

Cardiovascular Disease (1)

Infection (4)

Inflammation/Immunology (38)

Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16990

Ac-YVAD-cmk 5+ Cited Publications caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P10084

Ac-VAD-pNA

Caspase Others

Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .
HY-W792412

Z-YVAD-CMK

Caspase Cancer

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor .
HY-136728

Ac-YVAD-AOM

Caspase Cancer

Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity .
HY-P5938

Ac-AAVALLPAVLLALLAP-YVAD-CHO

Caspase Cancer

Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable caspase-1 inhibitor that has antitumor activity .
HY-P5974

Z-YVAD-pNA

Z-Tyr-Val-Ala-Asp-pNA
Caspase Others

Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate .
HY-P4547

Ac-Trp-Glu-His-Asp-AMC

AC-WEHD-AMC
Caspase Others

Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
HY-P5122

Z-LEED-FMK

Caspase Inflammation/Immunology

Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .

Z-YVAD-CMK	Caspase	Cancer
Z-YVAD-CMK is a *caspase-1* and *caspase-3* inhibitor .

Ac-YVAD-AOM	Caspase	Cancer
Ac-YVAD-AOM is the inhibitor of *caspase*-1 that shows antitumor activity .

Ac-AAVALLPAVLLALLAP-YVAD-CHO	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable *caspase*-1 inhibitor that has antitumor activity .

Z-YVAD-pNA Z-Tyr-Val-Ala-Asp-pNA	Caspase	Others
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a *caspase-1* substrate .

Ac-Trp-Glu-His-Asp-AMC AC-WEHD-AMC	Caspase	Others
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a *caspase-13* and *caspase-4* inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

HY-P2377

Ac-YVAD-AFC 1 Publications Verification	Fluorescent Dye	Others
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) .

HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde

Caspase Inflammation/Immunology

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a K_i value of 56 pM .
HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA

Cholinesterase (ChE) Caspase Others

Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .
HY-153068

CZL55

Caspase Inflammation/Immunology

CZL55 is a caspase-1 inhibitor with an IC₅₀ value of 24 nM. CZL55 can be used for the research of febrile seizures (FS) .

Ac-Trp-Glu-His-Asp-Aldehyde	Caspase	Inflammation/Immunology
Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective *caspase-1* inhibitor with a K_i value of 56 pM .

Mca-YVADAP-Lys(Dnp)-OH TFA	Cholinesterase (ChE) Caspase	Others
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

CZL55	Caspase	Inflammation/Immunology
CZL55 is a *caspase-1* inhibitor with an IC₅₀ value of 24 nM. CZL55 can be used for the research of febrile seizures (FS) .

HY-131204

CZL80	Caspase	Neurological Disease
CZL80, a brain-penetrable *caspase-1* inhibitor with an IC₅₀ of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility .

HY-156415

NLRP3 agonist 2

NOD-like Receptor (NLR) Inflammation/Immunology

NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates Caspase-1 in THP1 cells .

NLRP3 agonist 2	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates *Caspase-1* in THP1 cells .

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Caspase	Others
Ac-Tyr-Val-Lys-Asp-aldehyde is a *caspase-1* inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia .

HY-152670

JC2-11	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1 .

HY-121988

INF4E	NOD-like Receptor (NLR)	Inflammation/Immunology
INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction .

HY-13205

Belnacasan 90+ Cited Publications VX-765	Caspase	Inflammation/Immunology
Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with K_is of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC₅₀ of ~0.7 μM .

HY-W041489

Chelidonic acid 1 Publications Verification	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-141622

SDZ 224-015	Interleukin Related Caspase SARS-CoV	Infection Inflammation/Immunology
SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and *caspase-1*. SDZ 224-015 possesses anti-COVID-19 activity, targeting M ^pro (IC₅₀ of 30 nM) .

HY-101019

Ossirene 1 Publications Verification AS101	Interleukin Related Caspase	Inflammation/Immunology Cancer
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor . Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits *Caspase-1* and is used for the autoimmune diseases and certain malignancies .

HY-156413

NLRP3 agonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms .

HY-107541

O-1602 1 Publications Verification	GPR55	Neurological Disease
O-1602 is an agonist of GPR55 (G protein-coupled receptor 55). O-1602 reduces the number and activation of hippocampal microglia induced by METH (methamphetamine). O-1602 decreases the expression levels of NLRP3 inflammasome proteins, including NLRP3, ASC and Caspase-1 .

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a *caspase-1* inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .

HY-120019A

Ac-YVAD-CHO acetate L-709049 acetate	Interleukin Related Caspase Apoptosis	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a *caspase-1* inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-146765

AMS-17	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-α, IL-1β and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders .

HY-N0619

Mulberroside A 2 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-B1138

Fenbufen CL-82204	COX Caspase	Inflammation/Immunology
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .

HY-101092

QS-21 1 Publications Verification Stimulon	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

HY-111662

Fc 11a-2	NOD-like Receptor (NLR)	Inflammation/Immunology
Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis .

HY-W650842

Boc-Asp(OBzl)-CMK	Caspase	Cancer
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .

HY-10081

GS-6201 1 Publications Verification CVT-6883	Adenosine Receptor	Inflammation/Immunology
GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (K_i=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-148258

GDC-2394	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits IL-1β with IC₅₀s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation .

HY-B1138R

Fenbufen (Standard)	COX Caspase	Inflammation/Immunology
Fenbufen (Standard) is the analytical standard of Fenbufen. This product is intended for research and analytical applications. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .

HY-B1138S

Fenbufen-d9	Isotope-Labeled Compounds COX Caspase	Inflammation/Immunology
Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-155194

P2X7 receptor antagonist-4	Others	Inflammation/Immunology
P2X7 receptor antagonist-4 (Compound 14a) is a P2X7R antagonist. The P2X7 receptor antagonist-4 values of P2X7R IC₅₀ in human and mouse are 64.7 and 10.1 nM, respectively. P2X7 receptor antagonist-4 can inhibit the activation of NLRP3 inflammasome, thereby inhibiting the expression of caspase-1, gasdermin D, IL-1β and IL-18 in the damaged kidney of sepsis mice .

HY-155759

HMGB1-IN-2	Others	Inflammation/Immunology Cancer
HMGB1-IN-2 (compound 15) is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC₅₀ value of 20.2 μM in RAW264.7 cells. HMGB1-IN-2 (30 μM) decreases the level of IL-1 β, TNF-α, caspase-1 p20, inhibits the phosphorylation of NF-κB p65, exhibits anti-apoptotic activity. HMGB1-IN-2 (15 mg/kg; ip) relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC₅₀s of 77.0 μM, and 82.0 μM, respectively .

HY-111675

Ac-FLTD-CMK 4 Publications Verification	Caspase Pyroptosis	Inflammation/Immunology
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against *caspases-1* (IC₅₀ of 46.7 nM), *caspases-4* (IC₅₀ of 1.49 μM), *caspases-5* (IC₅₀ of 329 nM), and *caspases-11* , but not the apoptotic caspases such as caspase-3 .

HY-P1093

Ac-LEHD-AFC

1 Publications Verification

Caspase Others

Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

Ac-LEHD-AFC 1 Publications Verification	Caspase	Others
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-112226

VRT-043198 2 Publications Verification	Caspase Drug Metabolite	Inflammation/Immunology
VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits K_i values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively .

HY-P1095

Ivachtin caspase-3 Inhibitor VII	Caspase	Cardiovascular Disease Neurological Disease
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl *caspase-3* inhibitor with an IC₅₀ of 23 nM. Ivachtin has modest selectivity for the remaining caspases .

HY-P10240

Ac-WVAD-AMC

Fluorescent Dye Others

Ac-WVAD-AMC is a fluorogenic substrate for caspase 1 .
HY-P10243

Ac-VAD-CMK

Caspase Neurological Disease

Ac-VAD-CMK is a pan inhibitor for caspase 1 .
HY-P10236

Ac-WEHD-pNA

Caspase Others

Ac-WEHD-pNA is a colorimetric substrate for caspase 1, 4, 5 and 14, which is utilized to measure the caspase activity .

Cat. No.	Product Name

HY-L059

Pyroptosis Compound Library

1,266 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1,266 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

HY-L175

Inflammasomes related Compound Library

68 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 68 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P4429

Z-YVAD-AFC

Peptides Others

Z-YVAD-AFC is a fluorescent substrate for Caspase-1, which can be used to detect and measure the activity of Caspase-1 .
HY-P10084

Ac-VAD-pNA

Caspase Others

Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .
HY-W792412

Z-YVAD-CMK

Caspase Cancer

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor .
HY-136728

Ac-YVAD-AOM

Caspase Cancer

Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity .
HY-P5938

Ac-AAVALLPAVLLALLAP-YVAD-CHO

Caspase Cancer

Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable caspase-1 inhibitor that has antitumor activity .
HY-P5974

Z-YVAD-pNA

Z-Tyr-Val-Ala-Asp-pNA
Caspase Others

Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate .
HY-P4547

Ac-Trp-Glu-His-Asp-AMC

AC-WEHD-AMC
Caspase Others

Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
HY-P5122

Z-LEED-FMK

Caspase Inflammation/Immunology

Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

HY-P2377

Ac-YVAD-AFC 1 Publications Verification	Fluorescent Dye	Others
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH

Caspase Angiotensin-converting Enzyme (ACE) Others

Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .
HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde

Caspase Inflammation/Immunology

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a K_i value of 56 pM .
HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA

Cholinesterase (ChE) Caspase Others

Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Caspase	Others
Ac-Tyr-Val-Lys-Asp-aldehyde is a *caspase-1* inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia .

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a *caspase-1* inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-W650842

Boc-Asp(OBzl)-CMK	Caspase	Cancer
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .

HY-P10276

Ac-VAD-AFC

Peptides Cancer

Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .
HY-P10240

Ac-WVAD-AMC

Fluorescent Dye Others

Ac-WVAD-AMC is a fluorogenic substrate for caspase 1 .
HY-P10243

Ac-VAD-CMK

Caspase Neurological Disease

Ac-VAD-CMK is a pan inhibitor for caspase 1 .
HY-P10236

Ac-WEHD-pNA

Caspase Others

Ac-WEHD-pNA is a colorimetric substrate for caspase 1, 4, 5 and 14, which is utilized to measure the caspase activity .
HY-P10244

Ac-YVAD-FMK

Peptides Others

Ac-YVAD-FMK is an inhibitor for caspase 1-like protease .

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-P10142

Ac-YEVD-AMC	Fluorescent Dye	Others
Ac-YEVD-AMC is a fluorescent substrate of *caspase-1/11*. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-P1009

Z-YVAD-FMK Maximum Cited Publications 13 Publications Verification	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

HY-P10244F

Biotin-YVAD-FMK	Peptides	Infection
Biotin-YVAD-FMK is an inhibitor for vacuolar processing enzyme (VPE), with a 64% inhibition at 5 μM. Biotin-YVAD-FMK is an irreversible substrate for caspase 1 .

HY-P5890

YVAD-CHO	Interleukin Related Caspase	Neurological Disease
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor that can partially delay motoneurone death in lesioned facial nerve mice .

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible *caspase-1/5* inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .

HY-P2630

Suc-YVAD-pNA	Interleukin Related	Inflammation/Immunology
Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-N0619

Mulberroside A 2 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-101092

QS-21 1 Publications Verification Stimulon	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-N12235

Sarglaroids F	Structural Classification Ketones, Aldehydes, Acids Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .

HY-N0816

Polyphyllin VI 1 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Pyroptosis
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces *caspase-1*-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer .

HY-N6037

Gardenin B 1 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Source classification Rubiaceae Phenols Plants Gardenia jasminoides Ellis Disease Research Fields Cancer	Apoptosis
Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B induces cell death in human leukemia cells involves multiple caspases .

HY-N0530

Dryocrassin ABBA Dryocrassin	Infection Structural Classification Classification of Application Fields Dryopteridaceae Source classification Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields	Apoptosis Influenza Virus
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-122928

Rosamultic acid	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Plants Rosa multifoloraThunb	Apoptosis Caspase
Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of *caspases* .

Cat. No.	Product Name	Chemical Structure

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80622

	*Cleaved-Caspase 1* Antibody** CASP1; IL1BC; IL1BCE; caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45	WB, ICC/IF, IHC-F, IHC-P, ELISA	Human, Mouse
	Cleaved-Caspase 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 45 kDa, targeting to Cleaved-Caspase 1. It can be used for WB,ICC/IF,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse.

HY-P81232

	Caspase-1 p20 Antibody caspase-1 isoform alpha p20 subunit; CASP1; ICE; IL1BC; caspase-1 subunit p20; CASP 1; caspase 1 apoptosis related cysteine peptidase; caspase 1 apoptosis related cysteine protease; caspase1; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; CASP1_HUMAN; CASP1_MOUSE.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat,
	Caspase-1 p20 Antibody is an unconjugated, approximately 20/46 kDa, rabbit-derived, anti-Caspase-1 p20 polyclonal antibody. Caspase-1 p20 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, background without labeling.

HY-P80587

	Caspase 1 Antibody CASP1; IL1BC; IL1BCE; caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45	WB, IHC-P, ELISA	Human, Mouse, Rat
	Caspase 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 45 kDa, targeting to Caspase 1. It can be used for WB,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

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