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Results for "

antimalaria

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (3) Bacterial (1) Calcium Channel (4) Dengue virus (2) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (5) Flavivirus (2) HSV (1) IFNAR (2) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (1) Na+/K+ ATPase (1) NF-κB (3) Nucleoside Antimetabolite/Analog (1) Parasite (20) PI3K (1) PI4K (1) PKA (1) Potassium Channel (3) Sodium Channel (4) TGF-beta/Smad (4) TNF Receptor (2)
By Research Areas:	Cancer (13) Cardiovascular Disease (4) Infection (24) Inflammation/Immunology (6) Metabolic Disease (2)

By Targets:

Apoptosis (3)

Autophagy (3)

Bacterial (1)

Calcium Channel (4)

Dengue virus (2)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (5)

Flavivirus (2)

HSV (1)

IFNAR (2)

Isotope-Labeled Compounds (1)

Lactate Dehydrogenase (1)

Na+/K+ ATPase (1)

NF-κB (3)

Nucleoside Antimetabolite/Analog (1)

Parasite (20)

PI3K (1)

PI4K (1)

PKA (1)

Potassium Channel (3)

Sodium Channel (4)

TGF-beta/Smad (4)

TNF Receptor (2)

By Research Areas:

Cancer (13)

Cardiovascular Disease (4)

Infection (24)

Inflammation/Immunology (6)

Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12651A

Primaquine 3 Publications Verification	Parasite	Infection Cancer
Primaquine is a potent *antimalaria* agent and a potent gametocytocide in falciparum malaria. Primaquine prevents relapse in vivax and ovale malaria .

HY-N1677

2,6-Dimethoxy-1,4-benzoquinone	Bacterial Parasite	Infection Metabolic Disease Inflammation/Immunology Cancer
2,6-Dimethoxy-1,4-benzoquinone, a natural phytochemical, is a known haustorial inducing factor. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimalaria effects .

HY-N0176

Dihydroartemisinin Maximum Cited Publications 20 Publications Verification Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol	Parasite NF-κB Autophagy Apoptosis	Infection Cancer
Dihydroartemisinin is a potent *anti-malaria* agent.

HY-117897

CK-2-68	Parasite	Infection
CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC₅₀ of 40 nM .

HY-150598

CHMFL-PI4K-127	PI4K PI3K	Infection
CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor, with an IC₅₀ of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC₅₀ of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy .

HY-N0176S

Dihydroartemisinin-d3 Dihydroqinghaosu-d₃; β-Dihydroartemisinin-d₃; Artenimol-d₃	Parasite NF-κB Autophagy Apoptosis	Infection Cancer
Dihydroartemisinin-d₃ is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.

HY-126392

Isonardoperoxide

Parasite Infection

Isonardoperoxide is a potent antimalaria agent with an EC₅₀ of 0.6 μM for Plasnwdium fulciparum malaria .
HY-19556

(+)-SJ733

SJ000557733
Na+/K+ ATPase Parasite Infection

(+)-SJ733 is an anti-malaria agent which can also inhibit Na ⁺-ATPase PfATP4.

Isonardoperoxide	Parasite	Infection
Isonardoperoxide is a potent *antimalaria* agent with an EC₅₀ of 0.6 μM for Plasnwdium fulciparum malaria .

(+)-SJ733 SJ000557733	Na+/K+ ATPase Parasite	Infection
(+)-SJ733 is an *anti-malaria* agent which can also inhibit Na ⁺-ATPase PfATP4.

HY-N0176S3

Dihydroartemisinin-d5 Dihydroqinghaosu-d5; β-Dihydroartemisinin-d5; Artenimol-d5	Apoptosis Parasite Autophagy NF-κB Isotope-Labeled Compounds	Infection Cancer
Dihydroartemisinin-d₅ is deuterated labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is a potent *anti-malaria* agent.

HY-12651

Primaquine diphosphate 3 Publications Verification Primaquine phosphate; Primaquine bisphosphate	Parasite	Infection Cancer
Primaquine diphosphate is a potent *antimalaria* agent and a potent gametocytocide in falciparum malaria. Primaquine diphosphate prevents relapse in vivax and ovale malaria .

HY-P2261

STAD 2	PKA	Infection
STAD 2 is a potent and selective disruptor of PKA-RII, with a K_d of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism .

HY-153007

DHFR-IN-5	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a K_i value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity .

HY-162072

PfThrRS-IN-1	Parasite	Infection
PfThrRS-IN-1 (compound 11) is a potent inhibitor of Plasmodium falciparum threonyl tRNA synthetase (PfThrRS), with the IC₅₀ value of 0.1 μM. PfThrRS-IN-1 is a potent *antimalaria* agent .

HY-118865

Piperaquine tetraphosphate	Parasite	Infection
Piperaquine tetraphosphate is a potent *antimalaria* agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria .

HY-135648

PfDHODH-IN-1	Parasite Lactate Dehydrogenase DNA/RNA Synthesis	Infection
PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity .

HY-D0143

Quinine 3 Publications Verification	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-D0143B

Quinine hemisulfate hydrate	Parasite Potassium Channel	Infection
Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV, with an IC₅₀ of 169 μM .

HY-D0143R

Quinine (Standard)	Dengue virus Flavivirus Parasite Potassium Channel	Infection
Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-18684

SIBA 5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine	Nucleoside Antimetabolite/Analog HSV Parasite	Infection Metabolic Disease Cancer
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies .

HY-N1584

Halofuginone 5+ Cited Publications RU-19110	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584A

Halofuginone hydrobromide 5+ Cited Publications RU-19110 hydrobromide	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584B

Halofuginone hydrochloride RU-19110 hydrochloride	Calcium Channel DNA/RNA Synthesis Parasite Sodium Channel TGF-beta/Smad	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584AR

Halofuginone hydrobromide (Standard)	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-150725

ODN 1585	IFNAR TNF Receptor	Infection Inflammation/Immunology Cancer
ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .

HY-150725C

ODN 1585 sodium	TNF Receptor IFNAR	Cancer
ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 sodium can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .

STAD 2	PKA	Infection
STAD 2 is a potent and selective disruptor of PKA-RII, with a K_d of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism .

Cat. No.	Product Name	Category	Target	Chemical Structure