Small molecule peptides

By Targets:	Amino Acid Derivatives (1) Apelin Receptor (APJ) (1) Apoptosis (3) Bacterial (1) Caspase (1) E1/E2/E3 Enzyme (1) Fluorescent Dye (3) GCGR (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Necroptosis (2) PARP (1) Protease Activated Receptor (PAR) (1) SARS-CoV (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (2) Neurological Disease (1)

Targets Recommended: Small Interfering RNA (siRNA) ALCAM/CD166 Formyl Peptide Receptor (FPR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-60265

Boc-D-Cyclopropylglycine

Amino Acid Derivatives Others

Boc-D-Cyclopropylglycine is a small molecule peptide, it can be used for compounds synthesis .

Boc-D-Cyclopropylglycine	Amino Acid Derivatives	Others
Boc-D-Cyclopropylglycine is a small molecule peptide, it can be used for compounds synthesis .

HY-160473A

TAM557 TFA	Microtubule/Tubulin	Cancer
TAM557 TFA is a cytotoxic tubulysin compounds, which is modified to be used for conjugation to transport vehicles that are targeting molecules, such as proteins, peptides, small molecules or polymeric carriers which can carry a targeting principle .

HY-16664

SJ-172550 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
SJ-172550 is a small molecule inhibitor of MDMX; competes for the wild type p53 peptide binding to MDMX with an EC₅₀ of 5 μM.

HY-123617

AZ8838	Protease Activated Receptor (PAR)	Inflammation/Immunology
AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pK_i of 6.4 for hPAR2 .

HY-P10409

SHLP2 Small humanin-like peptide 2	Others Apoptosis	Others
SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases .

HY-D1103

SiR dye 1	Fluorescent Dye	Others
SiR dye 1 is a new silicon rhodamine-like fluorescent probe, and can be conjugated with small molecules, peptides and oligonucleotide aminogroups or proteins with antibodies .

HY-N0630

Shanzhiside methyl ester	GCGR	Neurological Disease
Shanzhiside methy lester is isolated from lamiophlomis rotata. Shanzhiside methyl ester is a small molecule *glucagon-like peptide-1 (GLP-1) receptor* agonist and has the ability to induce anti-allodynic tolerance .

HY-P1350

H-Lys-Trp-Lys-OH	Bacterial	Infection
H-Lys-Trp-Lys-OH is a small molecule peptide which displays antibacterial and antiviral activities extracted from patent CN 104072579 A, Compound AMP12.

HY-P10285

d-KLA Peptide D-(KLAKLAK)2	Mitochondrial Metabolism PARP Caspase	Cancer
d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects .

HY-153859

Ser-SNAC TFA	Others	Others
Ser-SNAC TFA is a small-molecule substrate for NRPS C domains. As for NRPSs, refers to nonribosomal peptide synthetases, are large multidomain proteins to catalyze the formation of biologically active natural products. Ser-SNAC TFA can be used for characterizing the substrate specificity of C domain-catalyzed peptide bond formation .

HY-157171

Ac-YR-NH2	Others	Inflammation/Immunology
Ac-YR-NH2 is a small molecule modulator of MHC class II antigen presentation. Ac-YR-NH2 can influence peptide binding by MHC II to influence immune response .

HY-D0819

CY5-SE 5+ Cited Publications Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester	Fluorescent Dye	Others
Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

HY-148263

Biotin-PEG-Thiol (MW 2000)	Fluorescent Dye	Cancer
Biotin-PEG-Thiol (MW 2000) is an active compound. Biotin-PEG-Thiol (MW 2000) is pegylated by binding to streptavidin or antibiotin with high affinity and specificity. Biotin-PEG-Thiol (MW 2000) can modify biomolecules, proteins, peptides and other small molecule materials. Biotin-PEG-Thiol (MW 2000) is widely used in the research of agent release and nano new materials .

HY-W348072

SARS-CoV-2-IN-59	SARS-CoV	Infection
SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule inhibitor of SARS-CoV-2 that targets the main protease (Mpro) of the coronavirus. SARS-CoV-2-IN-59 has a strong interaction with residues on Mpro (Met 165, Gln 166, Met 165, His 41, Gln 189) .

HY-103080

CMF019	Apelin Receptor (APJ)	Cardiovascular Disease
CMF019 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents . Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin .

HY-156087

Cholicamideβ	Apoptosis Necroptosis	Cancer
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

HY-156087G

Cholicamideβ (GMP)	Apoptosis Necroptosis	Cancer
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library	40 compounds
Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria. Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union. MCE offers a unique collection of 40 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Marine-Sourced Natural Product Library

40 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 40 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Type

HY-D0819

CY5-SE 5+ Cited Publications Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester	Fluorescent Dyes/Probes
Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

CY5-SE

5+ Cited Publications

Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester

Fluorescent Dyes/Probes

Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

HY-D1103

SiR dye 1	Fluorescent Dyes/Probes
SiR dye 1 is a new silicon rhodamine-like fluorescent probe, and can be conjugated with small molecules, peptides and oligonucleotide aminogroups or proteins with antibodies .

HY-156087G

Cholicamideβ (GMP)	Fluorescent Dye
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

Cholicamideβ (GMP)

Fluorescent Dye

Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

Cat. No.	Product Name	Type

HY-156087G

Cholicamideβ (GMP)	Biochemical Assay Reagents
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

Cholicamideβ (GMP)

Biochemical Assay Reagents

Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .

Cat. No.	Product Name	Target	Research Area

HY-60265

Boc-D-Cyclopropylglycine

Amino Acid Derivatives Others

Boc-D-Cyclopropylglycine is a small molecule peptide, it can be used for compounds synthesis .

Boc-D-Cyclopropylglycine	Amino Acid Derivatives	Others
Boc-D-Cyclopropylglycine is a small molecule peptide, it can be used for compounds synthesis .

HY-P3432

DfTat	Peptides	Others
DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection .

HY-P10409

SHLP2 Small humanin-like peptide 2	Peptides Apoptosis	Others
SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases .

HY-P10157

ARF(1-22)

Peptides Others

ARF(1-22) is potentially capable of intracellular penetration to deliver small molecules, proteins, imaging agents, and pharmaceutical nanocarriers .

ARF(1-22)	Peptides	Others
ARF(1-22) is potentially capable of intracellular penetration to deliver small molecules, proteins, imaging agents, and pharmaceutical nanocarriers .

HY-P10285

d-KLA Peptide D-(KLAKLAK)2	Mitochondrial Metabolism PARP Caspase	Cancer
d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0630

Shanzhiside methyl ester	Iridoids Terpenoids Labiatae Source classification Plants Helenium radiatum (Less.) Bierner	GCGR
Shanzhiside methy lester is isolated from lamiophlomis rotata. Shanzhiside methyl ester is a small molecule *glucagon-like peptide-1 (GLP-1) receptor* agonist and has the ability to induce anti-allodynic tolerance .

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Small molecule peptides

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

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