Gram-negative lipid A

By Targets:	Antibiotic (2) Bacterial (5) Fungal (1) Parasite (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Infection (5) Inflammation/Immunology (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103251

PF-5081090 LpxC-4	Antibiotic Bacterial	Infection
PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens .

HY-P3512

Iseganan IB-367	Bacterial Fungal Parasite	Infection
Iseganan is an anti-microbial peptide that is active against both *Gram-positive* and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research .

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 160+ Cited Publications LPS, from Escherichia coli (O55:B5)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

HY-130581

Lipid X	Bacterial Antibiotic	Infection
Lipid X is a novel monosaccharide precursor of Lipid A (the active moiety of gram-negative endotoxin). Lipid X is protective against endotoxin administered to mice and sheep and against life-threatening gram-negative infections in mice .

HY-158682

LpxC-IN-13

Bacterial Infection

LpxC-IN-13 (Compound 13) is a LpxC inhibitor, with an IC₅₀ 18.06 nM. LpxC-IN-13 effectively inhibits Gram-negative bacterial infection .

LpxC-IN-13	Bacterial	Infection
LpxC-IN-13 (Compound 13) is a LpxC inhibitor, with an IC₅₀ 18.06 nM. LpxC-IN-13 effectively inhibits Gram-negative bacterial infection .

HY-D1056C2

Lipopolysaccharides, from S. enterica serotype minnesota LPS, from Salmonella enterica (Serotype minnesota)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides (LPS) is a class of specific endotoxins that constitute one of the major components of the cell wall in Gram-negative bacteria. LPS is composed of three components: Lipid A, the core oligosaccharide, and the O-specific polysaccharide. LPS is a powerful immune stimulant capable of activating the host immune system, particularly by binding to the Toll-like receptor 4 (TLR4) on the surface of immune cells, which triggers an inflammatory response. This product is derived from Salmonella enterica of the Minnesota serotype. Lipopolysaccharides can be utilized in studies concerning the activation of the host immune system and its role in inflammation and immune regulation .

HY-130323

13-HPOT	Bacterial	Infection
13-HPOT, a linolenic fatty acid hydroperoxide, is an antibacterial agent. 13-HPOT has a strong dose response effect on three plant pathogen gram negative bacteria: Pectobacterium carotovorum, Pseudomonas syringae and Xanthomonas translucens. 13-HPOT can interact with the lipid representative of the inner bacterial plasma membrane .

Cat. No.	Product Name	Type

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 160+ Cited Publications LPS, from Escherichia coli (O55:B5)	Biochemical Assay Reagents
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

Lipopolysaccharides, from E. coli O55:B5

160+ Cited Publications

LPS, from Escherichia coli (O55:B5)

Biochemical Assay Reagents

Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

HY-D1056C2

Lipopolysaccharides, from S. enterica serotype minnesota LPS, from Salmonella enterica (Serotype minnesota)	Carbohydrates
Lipopolysaccharides (LPS) is a class of specific endotoxins that constitute one of the major components of the cell wall in Gram-negative bacteria. LPS is composed of three components: Lipid A, the core oligosaccharide, and the O-specific polysaccharide. LPS is a powerful immune stimulant capable of activating the host immune system, particularly by binding to the Toll-like receptor 4 (TLR4) on the surface of immune cells, which triggers an inflammatory response. This product is derived from Salmonella enterica of the Minnesota serotype. Lipopolysaccharides can be utilized in studies concerning the activation of the host immune system and its role in inflammation and immune regulation .

Lipopolysaccharides, from S. enterica serotype minnesota

LPS, from Salmonella enterica (Serotype minnesota)

Carbohydrates

Lipopolysaccharides (LPS) is a class of specific endotoxins that constitute one of the major components of the cell wall in Gram-negative bacteria. LPS is composed of three components: Lipid A, the core oligosaccharide, and the O-specific polysaccharide. LPS is a powerful immune stimulant capable of activating the host immune system, particularly by binding to the Toll-like receptor 4 (TLR4) on the surface of immune cells, which triggers an inflammatory response. This product is derived from Salmonella enterica of the Minnesota serotype. Lipopolysaccharides can be utilized in studies concerning the activation of the host immune system and its role in inflammation and immune regulation .

Cat. No.	Product Name	Target	Research Area

HY-P3512

Iseganan IB-367	Bacterial Fungal Parasite	Infection
Iseganan is an anti-microbial peptide that is active against both *Gram-positive* and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 160+ Cited Publications LPS, from Escherichia coli (O55:B5)	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Saccharides	Toll-like Receptor (TLR)
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

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Gram-negative lipid A

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