Enolase

By Targets:	Enolase (7) Antibiotic (2) Apoptosis (3) Bacterial (2) Endogenous Metabolite (1)
By Research Areas:	Cancer (5) Infection (2) Metabolic Disease (6) Neurological Disease (1)

Targets Recommended: Enolase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141412

D-(-)-3-Phosphoglyceric acid disodium 3-Phospho-D-glyceric acid disodium	Enolase	Infection
D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalysed process of glycolysis. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast *enolase* .

HY-131904A

Hex

Enolase Metabolic Disease

Hex is an enolase inhibitor, with K_i values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively .

Hex	Enolase	Metabolic Disease
Hex is an *enolase* inhibitor, with K_i values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively .

HY-15858A

AP-III-a4 hydrochloride Maximum Cited Publications 7 Publications Verification ENOblock hydrochloride	Enolase Apoptosis	Metabolic Disease Cancer
AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue *enolase* inhibitor with an IC₅₀ of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic .

HY-P2862

Enolase

Others Others

Enolase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

*Enolase*	Others	Others
Enolase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-113167

2-Phosphoglyceric acid DL-2-phosphoglyceric acid	Endogenous Metabolite	Metabolic Disease
2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolysis substrate. It is catalyzed by enolase into phosphoenolpyruvate (PEP) .

HY-15858

AP-III-a4 Maximum Cited Publications 7 Publications Verification ENOblock	Enolase Apoptosis	Metabolic Disease Cancer
AP-III-a4 (ENOblock) is a nonsubstrate analogue *enolase* inhibitor with an IC₅₀ of 0.576 uM. AP-III-a4 can be used for the research of cancer and diabetic .

HY-108438

TCS 2210	Others	Neurological Disease
TCS 2210 (compound 1) is a neuronal differentiation inducer in mesenchymal stem cells (MSCs). TCS 2210 increases expression of the neuronal markers β-III tubulin and neuron-specific enolase (NSE) .

HY-117778

SF2312	Enolase Bacterial Antibiotic	Infection Cancer
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent *Enolase* inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-117778B

SF2312 ammonium	Enolase Bacterial Antibiotic	Cancer
SF2312 ammonium is the ammonium form of SF2312. SF2312 is a phosphonate antibiotic and *enolase* inhibitor. SF2312 can be isolated from actinomycete Micromonospora, which is active under anaerobic conditions. SF2312 is selectively toxic to ENO1-deleted glioma cells .

HY-131904

POMHEX 1 Publications Verification	Enolase Apoptosis	Metabolic Disease Cancer
POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor .

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library	709 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 709 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

709 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 709 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P4698

Tri-valine NSC 35938	Peptides	Metabolic Disease
Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-117778

SF2312	Structural Classification Natural Products Microorganisms Source classification	Enolase Bacterial Antibiotic
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent *Enolase* inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-113167

2-Phosphoglyceric acid DL-2-phosphoglyceric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolysis substrate. It is catalyzed by enolase into phosphoenolpyruvate (PEP) .

Species:	Human (4) Rat (1) Mouse (1)
Tag:	His (6)
Source:	E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P70271

	*Gamma-enolase/Enolase* 2 Protein, Human (His)** rHuGamma-Enolase/ENO2, His; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE; ENO2	Human	E. coli
	Gamma-enolase/Enolase 2 protein exhibits neurotrophic and neuroprotective properties, binding to neocortical neurons and promoting cell survival through a calcium-dependent mechanism. This suggests its potential role in supporting neuron viability within the central nervous system. Gamma-enolase/Enolase 2 Protein, Human (His) is the recombinant human-derived Gamma-enolase/Enolase 2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Gamma-enolase/Enolase 2 Protein, Human (His) is 434 a.a., with molecular weight of ~60 kDa.

HY-P75732

	Enolase 3/ENO3 Protein, Human (His) Beta-Enolase; Enolase 3; MSE; Skeletal muscle Enolase	Human	E. coli
	Enolase 3/ENO3 protein acts as a glycolytic enzyme, promoting the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In addition to its role in glycolysis, ENO3 appears to play a crucial role in the development and regeneration of striated muscle. Enolase 3/ENO3 Protein, Human (His) is the recombinant human-derived Enolase 3/ENO3 protein, expressed by E. coli , with N-His labeled tag. The total length of Enolase 3/ENO3 Protein, Human (His) is 434 a.a., with molecular weight of ~45 kDa.

HY-P75253

	Enolase 1/ENO1 Protein, Rat (His) ENO1L1; Eno-1; Alpha-Enolase; NNE; MBP-1; Enolase 1	Rat	E. coli
	Enolase 1 (ENO1) plays a pivotal role in carbohydrate degradation, specifically in the glycolytic pathway, where it catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate. This enzymatic activity occurs during the fourth step of glycolysis, marking a crucial stage in the conversion of glucose to pyruvate. As a key player in glycolysis, ENO1 contributes to the energy production process by facilitating the generation of pyruvate, a central metabolite in cellular metabolism. This step underscores the essential function of ENO1 in maintaining energy homeostasis and supporting various cellular processes reliant on glycolytic intermediates. Enolase 1/ENO1 Protein, Rat (His) is the recombinant rat-derived Enolase 1/ENO1 protein, expressed by E. coli , with N-His labeled tag. The total length of Enolase 1/ENO1 Protein, Rat (His) is 434 a.a., with molecular weight of ~49.4 kDa.

HY-P72182

	Enolase 1/ENO1 Protein, Mouse (His) Eno1; Eno-1; Alpha-Enolase; EC 4.2.1.11; 2-phospho-D-glycerate hydro-lyase; Enolase 1; Non-neural Enolase; NNE	Mouse	E. coli
	Enolase 1/ENO1 Proteins, as a glycolytic enzyme, convert 2-phosphoglycerate to phosphoenolpyruvate and have diverse roles in cellular processes like growth control, hypoxia tolerance, and allergic responses. They also function in the fibrinolytic system and stimulate immunoglobulin production, showing their involvement in immune responses. Enolase 1/ENO1 Protein, Mouse (His) is the recombinant mouse-derived Enolase 1/ENO1 protein, expressed by E. coli , with N-10*His labeled tag. The total length of Enolase 1/ENO1 Protein, Mouse (His) is 432 a.a., with molecular weight of ~50.4 kDa.

HY-P70260

	Enolase 1/ENO1 Protein, Human (His) rHuAlpha-Enolase, His; Alpha-Enolase; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural Enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein; ENO1	Human	E. coli
	Alpha-enolase/Enolase 1 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Alpha-enolase, a multifunctional protein, is a key glycolytic enzyme in the cytoplasm of prokaryotic and eukaryotic cells.

HY-P70260A

	Enolase 1/ENO1 Protein, Human (C-His) rHuAlpha-Enolase, His; Alpha-Enolase; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural Enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein; ENO1	Human	E. coli
	The ENO1 Protein operates as a glycolytic enzyme, catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to its role in glycolysis, ENO1 is implicated in various processes such as growth control, hypoxia tolerance, and allergic responses. Notably, it displays versatility by potentially functioning in the intravascular and pericellular fibrinolytic system, acting as a receptor and activator of plasminogen on the cell surface of diverse cell types including leukocytes and neurons. ENO1's ability to stimulate immunoglobulin production further underscores its multifaceted functions. Moreover, it binds to the myc promoter and acts as a transcriptional repressor, suggesting a regulatory role in gene expression. Additionally, ENO1 may function as a tumor suppressor, implicating its involvement in cellular processes that extend beyond glycolysis and impact critical aspects of growth control and immune responses. Enolase 1/ENO1 Protein, Human (C-His) is the recombinant human-derived Enolase 1/ENO1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Enolase 1/ENO1 Protein, Human (C-His) is 434 a.a., with molecular weight of 49 kDa.


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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81290B

	NSE Antibody (YA1006) ENO2; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	NSE Antibody (YA1006) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1006), targeting NSE, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). NSE Antibody (YA1006) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P81290

	NSE Antibody (YA1004) ENO2; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE	WB, ELISA	Human, Mouse, Rat
	NSE Antibody (YA1004) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1004), targeting NSE, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). NSE Antibody (YA1004) can be used for WB, ELISA experiment in human, mouse, rat background.

HY-P81290A

	NSE Antibody (YA1005) ENO2; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE	WB, ELISA	Human, Mouse, Rat
	NSE Antibody (YA1005) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1005), targeting NSE, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). NSE Antibody (YA1005) can be used for WB, ELISA experiment in human, mouse, rat background.

HY-P81290C

	NSE Antibody (YA1007) ENO2; Gamma-Enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural Enolase; Neuron-specific Enolase; NSE	WB, ELISA	Human, Mouse, Rat
	NSE Antibody (YA1007) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1007), targeting NSE, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). NSE Antibody (YA1007) can be used for WB, ELISA experiment in human, mouse, rat background.

HY-P83023

	ENO3 Antibody (YA2768) Enolase 3; MSE; GSD13	WB, ICC/IF	Human, Mouse, Rat
	ENO3 Antibody (YA2768) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2768), targeting ENO3, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). ENO3 Antibody (YA2768) can be used for WB, ICC/IF experiment in human, mouse, rat background.

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