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Cinchona

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

14

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N7354
    Quininic acid

    		Others Cardiovascular Disease
    Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid .
    Quininic acid
  • HY-N0173
    Cinchonidine

    α-Quinidine

    		 Serotonin Transporter Parasite Infection
    Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities .
    Cinchonidine
  • HY-42034
    Hydroquinine

    Dihydroquinine

    		 Others Inflammation/Immunology
    Hydroquinine is a cinchona alkaloid, can be used in the preparation of its derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine and 10,11-dihydroquinine monohydrochloride .
    Hydroquinine
  • HY-W011241
    Cinchonine hydrochloride

    (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride

    		 Apoptosis Parasite Cancer
    Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells .
    Cinchonine hydrochloride
  • HY-N10833
    2-Hydroxy-1,3,4-trimethoxyanthraquinone

    		Others Others
    2-Hydroxy-1,3,4-trimethoxyanthraquinone is a anthraquinone that can be found in Cinchona ledgeriana .
    2-Hydroxy-1,3,4-trimethoxyanthraquinone
  • HY-D0143
    Quinine
    3 Publications Verification

    		 Flavivirus Dengue virus Parasite Potassium Channel Infection
    Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
    Quinine
  • HY-42034R
    Hydroquinine (Standard)

    		Others Inflammation/Immunology
    Hydroquinine (Standard) is the analytical standard of Hydroquinine. This product is intended for research and analytical applications. Hydroquinine is a cinchona alkaloid, can be used in the preparation of its derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine and 10,11-dihydroquinine monohydrochloride .
    Hydroquinine (Standard)
  • HY-D0143B
    Quinine hemisulfate hydrate

    		Parasite Potassium Channel Infection
    Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV, with an IC50 of 169 μM .
    Quinine hemisulfate hydrate
  • HY-D0143A
    Quinine dihydrochloride

    		Flavivirus Dengue virus Parasite Potassium Channel Infection
    Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
    Quinine dihydrochloride
  • HY-B0433B
    Quinine hemisulfate

    		Flavivirus Dengue virus Parasite Potassium Channel Infection
    Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
    Quinine hemisulfate
  • HY-Y0152
    Cinchonine
    2 Publications Verification

    (8R,9S)-Cinchonine; LA40221

    		 Apoptosis Parasite Autophagy Caspase Calcium Channel Others Inflammation/Immunology Cancer
    Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .
    Cinchonine
  • HY-W010668
    Quinine sulfate hydrate
    3 Publications Verification

    		 Flavivirus Dengue virus Parasite Potassium Channel Others
    Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
    Quinine sulfate hydrate
  • HY-D0143R
    Quinine (Standard)

    		Dengue virus Flavivirus Parasite Potassium Channel Infection
    Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
    Quinine (Standard)
  • HY-B1751H
    Quinidine

    		Sodium Channel Parasite Infection Cardiovascular Disease
    Quinidine is a stereoisomer of Quinine (HY-D0143), a natural compound derived from the bark of the South American cinchona tree. Quinidine is one of the earliest known antiarrhythmic agents and is available as a Class 1a antiarrhythmic and antimalarial drug. Quinidine inhibits the rapid inward sodium current, resulting in the suppression of action potential phase 0. This mechanism suppresses the excitability of the heart muscle, ultimately leading to longer duration of action potentials and reduced automaticity. Quinidine shows a "use-dependent blocking" effect on the rapidly inward sodium current, meaning that the drug's effects increases at higher heart rates and decreases at lower heart rates.Quinidine can be used in the study of Plasmodium falciparum malaria and ventricular arrhythmias .
    Quinidine

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