COVID-19 Main Protease

Pathways Recommended:	Metabolic Enzyme/Protease

By Targets:	Virus Protease (4) CDK (1) Ceramidase (2) FAAH (2) Glutathione Peroxidase (2) Nucleoside Antimetabolite/Analog (2) SARS-CoV (13)
By Research Areas:	Cancer (5) Infection (13) Inflammation/Immunology (5) Neurological Disease (1)

Targets Recommended: CD19 Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) Ser/Thr Protease G protein-coupled Bile Acid Receptor 1 ClpP Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1739

Tectoquinone 2-Methylanthraquinone	SARS-CoV Virus Protease	Infection
Tectoquinone (2-Methylanthraquinone) is a SARSCoV-2 main protease inhibitor against COVID-19. Tectoquinone exhibits strong mosquito larvicidal activity with the LC₅₀ values of 3.3 and 5.4 μg/ml against A. aegypti and A. albopictus in 24 h, respectively .

HY-N5068

Isorhamnetin 7-O-α-L-rhamnoside

SARS-CoV Infection

Isorhamnetin 7-O-α-L-rhamnoside shows binding affinity with COVID-19 virus main protease .

Isorhamnetin 7-O-α-L-rhamnoside	SARS-CoV	Infection
Isorhamnetin 7-O-α-L-rhamnoside shows binding affinity with COVID-19 virus main protease .

HY-N8205

Hispidulin 4'-O-β-D-glucopyranoside	SARS-CoV	Infection Inflammation/Immunology
Hispidulin 4'-O-β-D-glucopyranosid, a natural compound, may serve as a potential COVID-19 main protease inhibitor .

HY-151477

SARS-CoV-2-IN-32	SARS-CoV	Infection Cancer
SARS-CoV-2-IN-32 (compound 3g) is a COVID-19 inhibitor. SARS-CoV-2-IN-32 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-32 exhibits comparatively high binding affinity (-8.8 Kcal/mole) to COVID-19 main protease (M ^pro) (PDB ID: 6LU7). SARS-CoV-2-IN-32 can be used in studies of cancer and COVID-19 .

HY-151478

SARS-CoV-2-IN-33	SARS-CoV	Infection Cancer
SARS-CoV-2-IN-33 (compound 3m) is a COVID-19 inhibitor. SARS-CoV-2-IN-33 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-33 exhibits comparatively good binding affinity (-8.0 Kcal/mole) to COVID-19 main protease (M ^pro) (PDB ID: 6LU7). SARS-CoV-2-IN-33 can be used in studies of cancer and COVID-19 .

HY-147516

SARS-CoV-2-IN-21	SARS-CoV	Infection
SARS-CoV-2-IN-21 (compound 10), a penicillin sulfone benzyl C6 derivative, is a potent SARS-CoV-2 main protease inhibitor, with an IC₅₀ of 5.3 μM. SARS-CoV-2-IN-21 can be used for COVID-19 research .

HY-155843

CDK9-IN-25	CDK SARS-CoV Virus Protease	Infection
CDK9-IN-25 (compound 4a) is an imidazopyrazine CDK9 inhibitor (IC₅₀: 0.24 μM). CDK9-IN-25 has good affinity to the main protease of COVID-19 and has antiviral activity against human coronavirus 229E (IC₅₀: 63.28 μM) .

HY-B0182

Carmofur 3 Publications Verification HCFU	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-N7073

Silymarin 5 Publications Verification	SARS-CoV	Infection Neurological Disease Inflammation/Immunology Cancer
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective *SARS-CoV-2 main* protease (M ^pro)** inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research .

HY-B0182R

Carmofur (Standard)	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-N144101

SARS-CoV MPro-IN-2	SARS-CoV	Infection
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 M ^pro with an IC₅₀ value of 72.07 nM. The main protease (M ^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19 .

HY-161722

SARS-CoV-2 Mpro-IN-21	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-21 (compound A8) is a potent SARS-CoV-2 and OVID-19 Main Protease M ^Pro inhibitor. SARS-CoV-2 Mpro-IN-21 shows excellent antioxidant activity in DPPH assay with an IC₅₀ of 0.36 mg/mL. SARS-CoV-2 Mpro-IN-21 also exhibits better antibacterial potency against Klebsiella with an IC₅₀ of 1.19 mg/mL .

HY-113732

Kazinol F	SARS-CoV	Infection Inflammation/Immunology
Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1739

Tectoquinone 2-Methylanthraquinone	Quinones Structural Classification Clausena heptaphylla (Roxb.) Wight & Arn. Anthraquinones Source classification Rutaceae Plants	SARS-CoV Virus Protease
Tectoquinone (2-Methylanthraquinone) is a SARSCoV-2 main protease inhibitor against COVID-19. Tectoquinone exhibits strong mosquito larvicidal activity with the LC₅₀ values of 3.3 and 5.4 μg/ml against A. aegypti and A. albopictus in 24 h, respectively .

HY-N7073

Silymarin 5 Publications Verification	Infection Structural Classification Natural Products Glycine soya Neurological Disease Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Inflammation/Immunology Disease Research Fields	SARS-CoV
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective *SARS-CoV-2 main* protease (M ^pro)** inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research .

HY-N5068

Isorhamnetin 7-O-α-L-rhamnoside	Infection Flavonols Structural Classification Flavonoids Classification of Application Fields Elaeagnaceae Source classification Phenols Polyphenols Hippophae rhamnoides subsp. sinensis Rousi Plants Disease Research Fields	SARS-CoV
Isorhamnetin 7-O-α-L-rhamnoside shows binding affinity with COVID-19 virus main protease .

HY-N8205

Hispidulin 4'-O-β-D-glucopyranoside	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	SARS-CoV
Hispidulin 4'-O-β-D-glucopyranosid, a natural compound, may serve as a potential COVID-19 main protease inhibitor .

HY-N144101

SARS-CoV MPro-IN-2	Infection Quinones Classification of Application Fields Source classification Plants Lithospermum canescens Lehm. Naphthalene Quinones Disease Research Fields Boraginaceae	SARS-CoV
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 M ^pro with an IC₅₀ value of 72.07 nM. The main protease (M ^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19 .

HY-113732

Kazinol F	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat	SARS-CoV
Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19 .

Species:	Virus (3)
Tag:	His (3) Avi (2)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P76590

SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi)

3CL Protease; 3CL Proteinase; 3C-like Main Protease; 3CL-Mpro; COVID-19; M Proteinase; Main Protease; Mpro
Virus E. coli
HY-P76589

SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His)

3CL Protease; 3CL Proteinase; 3C-like Main Protease; 3CL-Mpro; COVID-19; M Proteinase; Main Protease; Mpro
Virus Sf9 insect cells
HY-P76591

SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi)

3CL Protease; 3CL Proteinase; 3C-like Main Protease; 3CL-Mpro; COVID-19; M Proteinase; Main Protease; Mpro
Virus Sf9 insect cells


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COVID-19 Main Protease

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