CCR8

Isoforms Recommended:	CCR8

By Targets:	CCR (12) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Endocrinology (5) Infection (1) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144197

CCR8 antagonist 1

CCR Infection Inflammation/Immunology

CCR8 antagonist 1 (compound 15) is a potente human CCR8 antagonist with a K_i of 1.6 nM .

CCR8 antagonist 1	CCR	Infection Inflammation/Immunology
CCR8 antagonist 1 (compound 15) is a potente human *CCR8* antagonist with a K_i of 1.6 nM .

HY-144200

CCR8 antagonist 2	CCR	Neurological Disease Cancer
CCR8 antagonist 2 is a potent antagonist of *CCR8. CCR8* (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the research of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220) .

HY-160647

CCR8 antagonist 3	CCR	Inflammation/Immunology
CCR8 antagonist 3 (compound 2) is a *CCR8* antagonist with an IC₅₀ value of 0.062 µM. CCR8 antagonist 3 shows human microsomal stability .

HY-RS02169

CCR8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCR8 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCR8 Human Pre-designed siRNA Set A CCR8 Human Pre-designed siRNA Set A

HY-RS02170

Ccr8 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccr8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccr8 Mouse Pre-designed siRNA Set A Ccr8 Mouse Pre-designed siRNA Set A

HY-RS02171

Ccr8 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccr8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccr8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccr8 Rat Pre-designed siRNA Set A Ccr8 Rat Pre-designed siRNA Set A

HY-122219

R243	CCR	Inflammation/Immunology
R243 is a potent and selective *CCR8* antagonist. R243 inhibits *CCL₁/CCR8* interaction and inhibits *CCR8* signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects .

HY-124416

ML604086	CCR	Inflammation/Immunology Endocrinology
ML604086 is a selective *CCR8* inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca ²⁺ concentrations .

HY-101038A

ZK756326 dihydrochloride 1 Publications Verification	CCR	Endocrinology Cancer
ZK756326 dihydrochloride is a nonpeptide chemokine receptor agonist for the CC chemokine receptor *CCR8*.

HY-101038

ZK 756326

CCR Endocrinology Cancer

ZK756326 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8.
HY-153669

SB-649701

CCR Inflammation/Immunology

SB-649701 is a potent human CCR8 antagonist, with a pIC₅₀ of 7.7. AZ084 can be used for the research of asthma .

ZK 756326	CCR	Endocrinology Cancer
ZK756326 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor *CCR8*.

SB-649701	CCR	Inflammation/Immunology
SB-649701 is a potent human CCR8 antagonist, with a pIC₅₀ of 7.7. AZ084 can be used for the research of asthma .

HY-160658

AZ760	CCR	Inflammation/Immunology
AZ760 is a *CCR8* antagonist. AZ760 shows excellent potency, good lipophilicity and high free fraction in blood. AZ760 exhibits unacceptable hERG inhibition .

HY-153670

IPG7236	CCR	Cancer
IPG7236 is a selective *CCR8* antagonist. IPG7236 exhibits significant tumor suppression in a mouse xenograft model of human breast cancer. IPG7236 can be used in cancer research .

HY-121885

LMD-009 1 Publications Verification	CCR	Metabolic Disease Endocrinology
LMD-009 is a selective *CCR8* nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC₅₀s from 11 to 87 nM .

HY-119217

AZ084 2 Publications Verification	CCR	Inflammation/Immunology Endocrinology
AZ084 is a potent, selective, allosteric and oral active *CCR8* allosteric antagonist, with a K_i of 0.9 nM. Has potential to treat asthma . AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating Treg differentiation. AZ084 can be used in studies of asthma and cancer .

Recombinant Proteins Recommended:

CCR8

Species:	Human (2) Cynomolgus (1)
Tag:	His (2) Myc (1) Fc (1)
Source:	HEK293 (2) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700965

	CCR8 Protein, Cynomolgus (HEK293, mFc) CCR-8; CMKBRL2; CKR-L1; GPR-CY6; GPRCY6; TER1; CCR8; CKRL1; CMKBR8; CD198; ChemR1; CKR-L1; CY6; TER-1; CDw198	Cynomolgus	HEK293
	CCR8 is part of the G-protein coupled receptor 1 family. CCR8 Protein, Cynomolgus (HEK293, mFc) is the recombinant cynomolgus-derived CCR8 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CCR8 Protein, Cynomolgus (HEK293, mFc) is 35 a.a., with molecular weight of 35-45 kDa.

HY-P700400

	CCR8 Protein-VLP, Human (HEK293, His) CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973	Human	HEK293
	CCR8 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.

HY-P700543

	CCR8 Protein, Human (P. pastoris, His) CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973	Human	P. pastoris
	CCR8 Protein-VLP, a receptor for CCL1/SCYA1/I-309, may regulate monocyte chemotaxis and thymic cell line apoptosis. It also acts as an alternative coreceptor with CD4 for HIV-1 infection, facilitating viral entry. The interaction with CCL1 highlights its role in mediating cellular responses to this chemokine, implying a regulatory function in immune and inflammatory processes. CCR8 Protein, Human (P. pastoris, His) is the recombinant human-derived CCR8 protein, expressed by P. pastoris, with C-Myc, C-6*His labeled tag. The total length of CCR8 Protein, Human (P. pastoris, His) is 35 a.a., with molecular weight of 7.7 kDa.


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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81628

	CCR8 Antibody (YA1373) CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; TER1	FC, ELISA	Human
	CCR8 Antibody (YA1373) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1373), targeting CCR8. CCR8 Antibody (YA1373) can be used for FC, ELISA experiment in human background.

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