2. PROTAC Apoptosis
  3. Ligands for E3 Ligase Ferroptosis
  4. Ru-Poma

Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively.

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Ru-Poma Chemical Structure

Ru-Poma Chemical Structure

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Description

Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively[1].

Molecular Weight

1664.61

Formula

C89H75Cl2N11O11Ru.7H2O
SMILES

O=C1N(C(C2=C1C(NCCCOC3=CC=C(C4=NC5=C(C6=CC=C[N]7=C6C8=C5C=CC=[N]8[Ru+2]79([N]%10=CC=C(C(C=C%11)=C%10%12)C%13=CC=CC=C%13)([N]%14=CC=C(C%15=C%14C%16=[N]9C=CC(C%17=CC=CC=C%17)=C%16C=C%15)C%18=CC=CC=C%18)[N]%19=C%12C%11=C(C=C%19)C%20=CC=CC=C%20)N4C%21=CC=CC=C%21)C=C3)=CC=C2)=O)C%22CCC(NC%22=O)=O.O.O.O.O.O.O.[Cl-].[Cl-].O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Ru-Poma Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ru-PomaLigands for E3 LigaseFerroptosisE3 ligase-recruiting MoietyA549photodynamic therapySW620Inhibitorinhibitorinhibit

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