RS-18286 

RS-18286 is a potent LHRH antagonist studied for its effects on pituitary hormone secretion in sexually active rams. Injection of RS-18286 resulted in an immediate suppression of pulsatile LH secretion, accompanied by a decrease in testosterone levels, while FSH and PRL levels remained unchanged. The duration of LH suppression was dose-related, lasting approximately 4.3 to 31.8 hours for low to high doses, respectively. During the recovery phase, a compensatory increase in LH pulse frequency was observed, suggesting a response to diminished testosterone feedback. Even at the lowest dose, RS-18286 transiently reduced testosterone levels, demonstrating an effect on acute hypothalamic sensitivity to changes in hormonal feedback^[1].

1523.61

C₇₄H₁₀₁Cl₂N₁₇O₁₄

109458-76-6

Ac-{d-Phe<Cl>}-{d-Phe<Cl>}-{d-Trp}-Ser-Tyr-{d-Har<Et,Et>}-Leu-Arg-Pro-{d-Ala}

Ac-{d-Phe<Cl>}-{d-Phe<Cl>}-{d-Trp}-SY-{d-Har<Et,Et>}-LRP-{d-Ala}

C[C@H](C(O)=O)NC([C@H]1N(C([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](CCCC/N=C(NCC)/NCC)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CO)NC([C@@H](CC3=CNC4=C3C=CC=C4)NC([C@@H](CC5=CC=C(Cl)C=C5)NC([C@@H](CC6=CC=C(Cl)C=C6)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lincoln GA, et al. Compensatory response of the luteinizing-hormone (LH)-releasing hormone (LHRH)/LH pulse generator after administration of a potent LHRH antagonist in the ram. Endocrinology. 1987 Jun;120(6):2245-50.  [Content Brief]