1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Reticulol

Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma.

For research use only. We do not sell to patients.

Reticulol Chemical Structure

Reticulol Chemical Structure

CAS No. : 26246-41-3

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Description

Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].

In Vitro

Reticulol (25-200 μM) shows a potent cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Reticulol (10 mg/kg, 50 mg/kg; iv; day 3 and day 5 after tumor implanted) inhibits tumor growth in mice bearing B16F10 melanoma, and shows lung metastasis-blocking effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free female C57BL/6J mice[1]
Dosage: 10 mg/kg, 50 mg/kg
Administration: IV via the tail vein; day 3 and day 5 after tumor implanted
Result: Inhibited tumor growth.
Molecular Weight

222.19

Formula

C11H10O5

CAS No.
SMILES

O=C1C2=C(O)C(OC)=C(O)C=C2C=C(C)O1

Structure Classification
Initial Source

Streptoverticillium album

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Reticulol
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HY-120241
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