Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human (HEK293, His, Avi)

HLA-E*0103 Complex, a non-classical major histocompatibility class Ib molecule, plays a pivotal role in immune self-nonself discrimination. This molecule forms a complex with B2M/beta-2-microglobulin and selectively binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules, specifically VL9 peptides (VMAPRT[V/L][L/V/I/F]L). The peptide-bound HLA-E-B2M heterotrimeric complex serves as a ligand for the inhibitory receptor KLRD1-KLRC1 on natural killer (NK) cells, enabling these cells to monitor the expression of other MHC class I molecules in healthy cells and tolerate self. During cellular stress, HLA-E*0103 preferentially binds signal sequence-derived peptides from stress-induced chaperones, resulting in impaired protection from NK cells. Moreover, it binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, acting as a ligand for the NK cell activating receptor KLRD1-KLRC2, potentially contributing to adaptive NK cell functions and maternal-fetal tolerance during pregnancy. Additionally, HLA-E*0103 can bind and present pathogen-derived peptides to alpha-beta T cell receptors on unconventional CD8-positive cytotoxic T cells, triggering an antimicrobial immune response. This molecule also presents specific peptides from viruses like human cytomegalovirus, facilitating immune tolerance to infected cells.

Human

HEK293

C-His;C-Avi

P13747 (G25-I305)&P61769 (I21-M119)

3133&567

50-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.