2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. (R)-Azetidine-2-carboxylic acid

(R)-Azetidine-2-carboxylic acid 

Cat. No.: HY-W017755 Assay: 99.20% ee.: 100%
COA Handling Instructions

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(R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be

For research use only. We do not sell to patients.

(R)-Azetidine-2-carboxylic acid Chemical Structure

(R)-Azetidine-2-carboxylic acid Chemical Structure

CAS No. : 7729-30-8

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Based on 1 publication(s) in Google Scholar

(R)-Azetidine-2-carboxylic acid Related Antibodies

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Description

(R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-Azetidine-2-carboxylic acid Related Antibodies
Molecular Weight

101.10

Formula

C4H7NO2
CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1NCC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.20% ee.: 100%

COA (249 KB) HNMR (180 KB) NP-HPLC (137 KB)

Handling Instructions (2659 KB)
References
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(R)-Azetidine-2-carboxylic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Azetidine-2-carboxylic acid7729-30-8ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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