2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. QWF Peptide

QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

QWF Peptide Chemical Structure

QWF Peptide Chemical Structure

CAS No. : 126088-82-2

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Based on 1 publication(s) in Google Scholar

QWF Peptide Related Antibodies

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Description

QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM[1].

IC50 & Target

IC50: 0.09 μM (substance P)[1]
Molecular Weight

697.78

Formula

C38H43N5O8
CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to off-white

Sequence

{Boc}-Gln-{d-Trp(Formyl)}-Phe-{OBzl}
Sequence Shortening

{Boc}-Q-{d-Trp(Formyl)}-F-{OBzl}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (143.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4331 mL 7.1656 mL 14.3312 mL
5 mM 0.2866 mL 1.4331 mL 2.8662 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4331 mL 7.1656 mL 14.3312 mL 35.8279 mL
5 mM 0.2866 mL 1.4331 mL 2.8662 mL 7.1656 mL
10 mM 0.1433 mL 0.7166 mL 1.4331 mL 3.5828 mL
15 mM 0.0955 mL 0.4777 mL 0.9554 mL 2.3885 mL
20 mM 0.0717 mL 0.3583 mL 0.7166 mL 1.7914 mL
25 mM 0.0573 mL 0.2866 mL 0.5732 mL 1.4331 mL
30 mM 0.0478 mL 0.2389 mL 0.4777 mL 1.1943 mL
40 mM 0.0358 mL 0.1791 mL 0.3583 mL 0.8957 mL
50 mM 0.0287 mL 0.1433 mL 0.2866 mL 0.7166 mL
60 mM 0.0239 mL 0.1194 mL 0.2389 mL 0.5971 mL
80 mM 0.0179 mL 0.0896 mL 0.1791 mL 0.4478 mL
100 mM 0.0143 mL 0.0717 mL 0.1433 mL 0.3583 mL
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QWF Peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QWF Peptide126088-82-2Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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