2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. PT150

PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease.

For research use only. We do not sell to patients.

PT150 Chemical Structure

PT150 Chemical Structure

CAS No. : 189035-07-2

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PT150 Related Antibodies

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Description

PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease[1][2].

In Vivo

PT150 (30, 100 mg/kg; p.o.; daily for 14 days) shows neuroprotective effects in rotenone (HY-B1756) induced Parkinson’s disease mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice (2.5 mg/kg/day rotenone by intraperitoneal injection for 14 days)[2]
Dosage: 30, 100 mg/kg
Administration: P.o.; daily for 14 days
Result: Reduced the loss of dopaminergic neuron (DAn) cell bodies in the substantia nigra (SN), but not the striatum, and prohibited intra-neuronal accumulation of α-synuclein (α-syn).
Molecular Weight

430.54

Formula

C28H30O4
CAS No.
SMILES

O[C@]1(C#CC)[C@]2(C)[C@H]([C@H](CC3)C([C@@H](C4=CC5=C(C=C4)OCO5)C2)=C6C3=CC(CC6)=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PT150 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PT150189035-07-2ORG-34517PT 150PT-150ORG34517ORG 34517Glucocorticoid Receptororally activeneuroprotectiveParkinson’s diseaserotenoneInhibitorinhibitorinhibit

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