2. Membrane Transporter/Ion Channel Anti-infection
  3. Sodium Channel Virus Protease
  4. Phenytoin-d10

Phenytoin-d10  (Synonyms: 5,5-Diphenylhydantoin-d10)

Cat. No.: HY-B0448S Purity: ≥98.0%
COA Handling Instructions

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Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

For research use only. We do not sell to patients.

Phenytoin-d<sub>10</sub> Chemical Structure

Phenytoin-d10 Chemical Structure

CAS No. : 65854-97-9

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1 mg USD 70 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Phenytoin-d10:

Phenytoin-d10 Related Antibodies

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  • Purity & Documentation

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Description

Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenytoin-d10 Related Antibodies
Molecular Weight

262.33

Formula

C15H2D10N2O2
CAS No.
Unlabeled Cas

57-41-0
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC(N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (190.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8120 mL 19.0600 mL 38.1199 mL
5 mM 0.7624 mL 3.8120 mL 7.6240 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8120 mL 19.0600 mL 38.1199 mL 95.2998 mL
5 mM 0.7624 mL 3.8120 mL 7.6240 mL 19.0600 mL
10 mM 0.3812 mL 1.9060 mL 3.8120 mL 9.5300 mL
15 mM 0.2541 mL 1.2707 mL 2.5413 mL 6.3533 mL
20 mM 0.1906 mL 0.9530 mL 1.9060 mL 4.7650 mL
25 mM 0.1525 mL 0.7624 mL 1.5248 mL 3.8120 mL
30 mM 0.1271 mL 0.6353 mL 1.2707 mL 3.1767 mL
40 mM 0.0953 mL 0.4765 mL 0.9530 mL 2.3825 mL
50 mM 0.0762 mL 0.3812 mL 0.7624 mL 1.9060 mL
60 mM 0.0635 mL 0.3177 mL 0.6353 mL 1.5883 mL
80 mM 0.0476 mL 0.2382 mL 0.4765 mL 1.1912 mL
100 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.9530 mL
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Phenytoin-d10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenytoin-d1065854-97-95,5-Diphenylhydantoin-d10Sodium ChannelVirus ProteaseNa channelsNa+ channelsInhibitorinhibitorinhibit

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