Phenothiazine-d₈

Name: Phenothiazine-d 8
Brand: MedChemExpress
SKU: HY-Y0055S
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y0055S Purity: 99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Phenothiazine-d₈ is the deuterium labeled Phenothiazine. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].

For research use only. We do not sell to patients.

Phenothiazine-d<sub>8</sub> Chemical Structure

Phenothiazine-d₈ Chemical Structure

CAS No. : 1219803-41-4

Size	Price	Stock	Quantity
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Phenothiazine-d₈:

Phenothiazine In-stock

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•Related Small Molecules:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

207.32

Formula

C₁₂HD₈NS

CAS No.

1219803-41-4

Unlabeled Cas

Appearance

Solid

Color

Light yellow to yellow

SMILES

[2H]C1=C2SC3=C([2H])C([2H])=C([2H])C([2H])=C3NC2=C([2H])C([2H])=C1[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (482.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8235 mL	24.1173 mL	48.2346 mL
5 mM	0.9647 mL	4.8235 mL	9.6469 mL
10 mM	0.4823 mL	2.4117 mL	4.8235 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.0%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Gao YQ, et al. Isolation and Characterization of Antifungal Metabolites from the Melia azedarach-Associated Fungus Diaporthe eucalyptorum. J Agric Food Chem. 2020 Feb 26;68(8):2418-2425. [Content Brief]

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[3]. Mitchell SC, et, al. The toxicity of phenothiazine. Drug Metabol Drug Interact. 1994;11(3):201-35. [Content Brief]

[4]. Ohlow MJ, et, al. Phenothiazine: the seven lives of pharmacology's first lead structure. Drug Discov Today. 2011 Feb;16(3-4):119-31.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8235 mL	24.1173 mL	48.2346 mL	120.5865 mL
	5 mM	0.9647 mL	4.8235 mL	9.6469 mL	24.1173 mL
	10 mM	0.4823 mL	2.4117 mL	4.8235 mL	12.0587 mL
	15 mM	0.3216 mL	1.6078 mL	3.2156 mL	8.0391 mL
	20 mM	0.2412 mL	1.2059 mL	2.4117 mL	6.0293 mL
	25 mM	0.1929 mL	0.9647 mL	1.9294 mL	4.8235 mL
	30 mM	0.1608 mL	0.8039 mL	1.6078 mL	4.0196 mL
	40 mM	0.1206 mL	0.6029 mL	1.2059 mL	3.0147 mL
	50 mM	0.0965 mL	0.4823 mL	0.9647 mL	2.4117 mL
	60 mM	0.0804 mL	0.4020 mL	0.8039 mL	2.0098 mL
	80 mM	0.0603 mL	0.3015 mL	0.6029 mL	1.5073 mL
	100 mM	0.0482 mL	0.2412 mL	0.4823 mL	1.2059 mL