2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. PF-05186462

PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain.

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PF-05186462 Chemical Structure

PF-05186462 Chemical Structure

CAS No. : 1235406-03-7

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Based on 1 publication(s) in Google Scholar

PF-05186462 Related Antibodies

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Description

PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain[1].

IC50 & Target

IC50: 21 nM (human Nav1.7)[1]
In Vitro

PF-05186462 inhibits human Nav1.7 channels (IC50=21 nM) in HEK293 cells[1].
PF-05186462 exhibits a high plasma protein binding rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-05186462 Related Antibodies
Essai clinique
Masse moléculaire

531.89

Formule

C19H10ClF4N5O3S2
CAS No.
SMILES

O=S(C1=CC(Cl)=C(OC2=CC=C(C(F)(F)F)C=C2C3=CC=NN=C3)C=C1F)(NC4=NN=CS4)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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PF-05186462 Related Classifications

  • Calculateur de molarité

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-051864621235406-03-7PF05186462PF 05186462Sodium ChannelNa channelsNa+ channelsNav1.7voltagesodiumchannelacutechronicpainInhibitorinhibitorinhibit

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