2. GPCR/G Protein Neuronal Signaling
  3. mAChR Cholinesterase (ChE)
  4. PCS1055

PCS1055 is a selective and competitive antagonist for muscarinic M4 receptor with an IC50 of 18.1 nM and a Kd of 5.72 nM. PCS1055 inhibits radioligand [3H]-NMS binding to the M4 receptor with a Ki of 6.5 nM. PCS1055 is also an inhibitor for AChE with IC50 of 22 nM and 120 nM for electric eel and human AChE, respectively.

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PCS1055 Chemical Structure

PCS1055 Chemical Structure

CAS No. : 357173-55-8

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Based on 1 publication(s) in Google Scholar

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Description

PCS1055 is a selective and competitive antagonist for muscarinic M4 receptor with an IC50 of 18.1 nM and a Kd of 5.72 nM. PCS1055 inhibits radioligand [3H]-NMS binding to the M4 receptor with a Ki of 6.5 nM. PCS1055 is also an inhibitor for AChE with IC50 of 22 nM and 120 nM for electric eel and human AChE, respectively[1][2].

IC50 & Target

mAChR4

18.1 nM (IC50)

mAChR4

5.72 nM (Kd)

hAChE

120 nM (IC50)

Molecular Weight

412.57

Formula

C27H32N4
CAS No.
SMILES

C12=NN=C(NCCC3CCN(CC4=CC=CC=C4)CC3)C=C1CCCC5=CC=CC=C52
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (242.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4238 mL 12.1192 mL 24.2383 mL
5 mM 0.4848 mL 2.4238 mL 4.8477 mL
View the Complete Stock Solution Preparation Table

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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4238 mL 12.1192 mL 24.2383 mL 60.5958 mL
5 mM 0.4848 mL 2.4238 mL 4.8477 mL 12.1192 mL
10 mM 0.2424 mL 1.2119 mL 2.4238 mL 6.0596 mL
15 mM 0.1616 mL 0.8079 mL 1.6159 mL 4.0397 mL
20 mM 0.1212 mL 0.6060 mL 1.2119 mL 3.0298 mL
25 mM 0.0970 mL 0.4848 mL 0.9695 mL 2.4238 mL
30 mM 0.0808 mL 0.4040 mL 0.8079 mL 2.0199 mL
40 mM 0.0606 mL 0.3030 mL 0.6060 mL 1.5149 mL
50 mM 0.0485 mL 0.2424 mL 0.4848 mL 1.2119 mL
60 mM 0.0404 mL 0.2020 mL 0.4040 mL 1.0099 mL
80 mM 0.0303 mL 0.1515 mL 0.3030 mL 0.7574 mL
100 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.6060 mL
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PCS1055 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCS1055357173-55-8PCS 1055PCS-1055mAChRCholinesterase (ChE)Muscarinic acetylcholine receptorselectivecompetitiveelectric eelInhibitorinhibitorinhibit

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