2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Octoclothepin maleate salt

Octoclothepin maleate salt  (Synonyms: Clorotepine maleate salt)

Cat. No.: HY-106587A Purity: 99.14%
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Octoclothepin maleate salt, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents.

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Octoclothepin maleate salt Chemical Structure

Octoclothepin maleate salt Chemical Structure

CAS No. : 4789-68-8

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Based on 1 publication(s) in Google Scholar

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Description

Octoclothepin maleate salt, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents[1][2].

In Vivo

Octoclothepin possesses high cataleptogenic and anti-apomorphine activities in rats; it is able to exert full protection against apomorphine-induced emesis in dogs after the dose of 0.1 mg/kg s.c.[1].
Octoclothepin in doses of 0.5 and 1.5 mg/kg s.c. reduces the DA level and raises the HVA and DOPAC levels significantly[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

460.97

Formula

C23H25ClN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(Cl)C=C24)CC1.O=C(O)/C=C\C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

45% SBE-β-CD in saline : ≥ 21 mg/mL (45.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1693 mL 10.8467 mL 21.6934 mL
5 mM 0.4339 mL 2.1693 mL 4.3387 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
45% SBE-β-CD in saline 1 mM 2.1693 mL 10.8467 mL 21.6934 mL 54.2335 mL
5 mM 0.4339 mL 2.1693 mL 4.3387 mL 10.8467 mL
10 mM 0.2169 mL 1.0847 mL 2.1693 mL 5.4233 mL
15 mM 0.1446 mL 0.7231 mL 1.4462 mL 3.6156 mL
20 mM 0.1085 mL 0.5423 mL 1.0847 mL 2.7117 mL
25 mM 0.0868 mL 0.4339 mL 0.8677 mL 2.1693 mL
30 mM 0.0723 mL 0.3616 mL 0.7231 mL 1.8078 mL
40 mM 0.0542 mL 0.2712 mL 0.5423 mL 1.3558 mL
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Octoclothepin maleate salt Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octoclothepin4789-68-8ClorotepineDopamine ReceptorneurolepticSR-2AD2DRdepressantInhibitorinhibitorinhibit

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