1. Metabolic Enzyme/Protease Apoptosis
  2. Endogenous Metabolite Apoptosis
  3. Niacin hydrochloride

Niacin hydrochloride  (Synonyms: Nicotinic acid hydrochloride; Vitamin B3 hydrochloride)

Cat. No.: HY-B0143A
Handling Instructions

Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases.

For research use only. We do not sell to patients.

Niacin hydrochloride Chemical Structure

Niacin hydrochloride Chemical Structure

CAS No. : 636-79-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Niacin hydrochloride:

Other Forms of Niacin hydrochloride:

Top Publications Citing Use of Products

    Niacin hydrochloride purchased from MedChemExpress. Usage Cited in: Glia. 2018 Feb;66(2):256-278.  [Abstract]

    Representative images and quantitative analysis showing the effects of Niacin (1 mM, 10 min) and MK-6892 (10 lM, 10 min) on Akt phosphorylation levels in primary cultured microglia.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism[1].
    Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    RT-PCR[1]

    Cell Line: Cumulus cells and oocytes of prepubertal gilts
    Concentration: 600 μM
    Incubation Time: 42 hours
    Result: Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX.

    Cell Proliferation Assay[2]

    Cell Line: Rat ascites hepatoma cell line of AH109A
    Concentration: 0-40 μM
    Incubation Time: 24 hours
    Result: Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.
    In Vivo

    Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice[3]
    Dosage: 3-300 mg/kg
    Administration: Subcutaneous injection; once
    Result: Induced vasodilation in a dose-dependent manner.
    Clinical Trial
    Molecular Weight

    159.57

    Formula

    C6H6ClNO2

    CAS No.
    SMILES

    O=C(C1=CC=CN=C1)O.Cl

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email Address *

    Phone Number *

     

    Organization Name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Niacin hydrochloride
    Cat. No.:
    HY-B0143A
    Quantity:
    MCE Japan Authorized Agent: