2. GPCR/G Protein
  3. CRFR
  4. NBI-34041

NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.

For research use only. We do not sell to patients.

NBI-34041 Chemical Structure

NBI-34041 Chemical Structure

CAS No. : 268545-87-5

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NBI-34041 Related Antibodies

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Description

NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.

IC50 & Target[1]

CRFR1

58.9 nM (IC50)

CRFR1

4 nM (Ki)

CRFR2

>10000 nM (IC50)

In Vitro

NBI-34041 could inhibit the production of cAMP in a concentration-dependent manner with an IC50 of approximately 60 nM. At concentrations of NBI-34041 up to 10 000 nM, NBI-34041 is unable to fully inhibit sauvagine stimulated cAMP from cells expressing the human CRF2 receptor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NBI-34041 Related Antibodies
In Vivo

NBI-34041 (3-30 mg/kg; oral gavage; a single dose) significantly attenuates the elevation in plasma ACTH induced by CRF. NBI-34041 also demonstrates efficacy in attenuating shock-induced ACTH release in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar or Sprague-Dawley rats (300-350 g)[1]
Dosage: 3 mg/kg, 10 mg/kg, or 30 mg/kg
Administration: Oral gavage; a single dose
Result: Did not impair diurnal adrenocorticotropic hormone (ACTH) and cortisol secretion or CRF evoked ACTH and cortisol responses but attenuated the neuroendocrine response to psychosocial stress.
Molecular Weight

417.37

Formula

C22H26Cl2N4
CAS No.
SMILES

CC1=NC2=C3C(N(C(CCC)CCC)CCN3N=C2C4=CC=C(Cl)C=C4Cl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NBI-34041 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NBI-34041268545-87-5SB-723620NBI34041NBI 34041SB723620SB 723620CRFRCorticotropin-releasing Factor ReceptorCRHRCRF1 receptor antagonistorally active nonpeptidedepressionanxiety disordersInhibitorinhibitorinhibit

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HY-14128
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