N1-Acetylspermidine-d₆ hydrochloride

Name: N1-Acetylspermidine-d 6 hydrochloride
Brand: MedChemExpress
SKU: HY-113056AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-113056AS Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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N1-Acetylspermidine-d₆ (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].

For research use only. We do not sell to patients.

N1-Acetylspermidine-d<sub>6</sub> hydrochloride Chemical Structure

N1-Acetylspermidine-d₆ hydrochloride Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 1420	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of N1-Acetylspermidine-d₆ hydrochloride:

N1-Acetylspermidine hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

266.24

Formula

C₉H₁₇D₆Cl₂N₃O

Unlabeled Cas

34450-16-3

Appearance

Solid

Color

White to off-white

SMILES

CC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])NCCCCN)=O.Cl.[2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H2O : 25 mg/mL (93.90 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7560 mL	18.7800 mL	37.5601 mL
5 mM	0.7512 mL	3.7560 mL	7.5120 mL
10 mM	0.3756 mL	1.8780 mL	3.7560 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (271 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84. [Content Brief]

[3]. Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. [Content Brief]

[4]. Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	3.7560 mL	18.7800 mL	37.5601 mL	93.9002 mL
	5 mM	0.7512 mL	3.7560 mL	7.5120 mL	18.7800 mL
	10 mM	0.3756 mL	1.8780 mL	3.7560 mL	9.3900 mL
	15 mM	0.2504 mL	1.2520 mL	2.5040 mL	6.2600 mL
	20 mM	0.1878 mL	0.9390 mL	1.8780 mL	4.6950 mL
	25 mM	0.1502 mL	0.7512 mL	1.5024 mL	3.7560 mL
	30 mM	0.1252 mL	0.6260 mL	1.2520 mL	3.1300 mL
	40 mM	0.0939 mL	0.4695 mL	0.9390 mL	2.3475 mL
	50 mM	0.0751 mL	0.3756 mL	0.7512 mL	1.8780 mL
	60 mM	0.0626 mL	0.3130 mL	0.6260 mL	1.5650 mL
	80 mM	0.0470 mL	0.2348 mL	0.4695 mL	1.1738 mL