N,N'-Dimethylhydrazine dihydrochloride (Synonyms: 1,2-Dimethylhydrazine dihydrochloride)

Cat. No.: HY-W460407 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride is a tumor inducer that induces colon tumors in rodents.

For research use only. We do not sell to patients.

N,N'-Dimethylhydrazine dihydrochloride Chemical Structure

CAS No. : 306-37-6

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Description

N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride is a tumor inducer that induces colon tumors in rodents^[1]^[2].

In Vivo

N,N'-Dimethylhydrazine (DMH) (20 mg/kg; sc; once weekly, 24 wk) can induce colon cancer in ICR mice^[1].
N,N'-Dimethylhydrazine (20 mg/kg ; sc; 20 wk) induces intraperitoneal intestinal tumors in rats, an effect that is potently inhibited by Lactobacillus acidophilus. Mice that consumed a beef diet that mimicked a "Western" diet had a higher incidence of colon cancer than grain-fed mice (83% vs. 31%, respectively)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ICR mouse^[1]
Dosage:	20 mg/kg
Administration:	sc; once weekly for 24 weeks; sacrificed mouse after between 23 and 33 weeks.
Result:	Induced colon cancer in ICR mice.

Animal Model:	Male inbred F344 rats^[1]
Dosage:	20 mg, 4 mg/mL dissolved in normal saline containing 1.5% EDTA (pH 6.4 and filter sterilized)
Administration:	sc; weekly for 20 or 35 weeks
Result:	Produced a higher incidence of adenocarcinomas in the small and large intestines of animals that were consuming the meat diet.

Molecular Weight

133.02

Formula

C₂H₁₀Cl₂N₂

CAS No.

306-37-6

Appearance

Solid

Color

White to off-white

SMILES

CNNC.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 175 mg/mL (1315.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5177 mL	37.5883 mL	75.1767 mL
5 mM	1.5035 mL	7.5177 mL	15.0353 mL
10 mM	0.7518 mL	3.7588 mL	7.5177 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (644 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Nakamura S, et al. Morphogenesis of colonic adenomas in mice treated with N,N'-dimethylhydrazine dihydrochloride. Acta Pathol Jpn. 1982 May;32(3):473-81. [Content Brief]

[2]. Goldin BR, et al. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J Natl Cancer Inst. 1980 Feb;64(2):263-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.5177 mL	37.5883 mL	75.1767 mL	187.9417 mL
	5 mM	1.5035 mL	7.5177 mL	15.0353 mL	37.5883 mL
	10 mM	0.7518 mL	3.7588 mL	7.5177 mL	18.7942 mL
	15 mM	0.5012 mL	2.5059 mL	5.0118 mL	12.5294 mL
	20 mM	0.3759 mL	1.8794 mL	3.7588 mL	9.3971 mL
	25 mM	0.3007 mL	1.5035 mL	3.0071 mL	7.5177 mL
	30 mM	0.2506 mL	1.2529 mL	2.5059 mL	6.2647 mL
	40 mM	0.1879 mL	0.9397 mL	1.8794 mL	4.6985 mL
	50 mM	0.1504 mL	0.7518 mL	1.5035 mL	3.7588 mL
	60 mM	0.1253 mL	0.6265 mL	1.2529 mL	3.1324 mL
	80 mM	0.0940 mL	0.4699 mL	0.9397 mL	2.3493 mL
	100 mM	0.0752 mL	0.3759 mL	0.7518 mL	1.8794 mL

N,N'-Dimethylhydrazine dihydrochloride Related Classifications

Biochemical Assay Reagents

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N'-Dimethylhydrazine306-37-61,2-DimethylhydrazineBiochemical Assay Reagentstumor inducerInhibitorinhibitorinhibit

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