2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Moclobemide-d4

Moclobemide-d4  (Synonyms: Ro111163-d4)

Cat. No.: HY-B0534S1 Purity: ≥99.0%
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Moclobemide-d4 is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

For research use only. We do not sell to patients.

Moclobemide-d<sub>4</sub> Chemical Structure

Moclobemide-d4 Chemical Structure

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1 mg USD 452 In-stock
5 mg USD 1040 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Moclobemide-d4:

Moclobemide-d4 Related Antibodies

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Description

Moclobemide-d4 is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Moclobemide-d4 Related Antibodies
Molecular Weight

272.76

Formula

C13H13D4ClN2O2
Unlabeled Cas

71320-77-9
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCN1CCOCC1)C2=C([2H])C([2H])=C(Cl)C([2H])=C2[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (366.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6662 mL 18.3311 mL 36.6623 mL
5 mM 0.7332 mL 3.6662 mL 7.3325 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6662 mL 18.3311 mL 36.6623 mL 91.6557 mL
5 mM 0.7332 mL 3.6662 mL 7.3325 mL 18.3311 mL
10 mM 0.3666 mL 1.8331 mL 3.6662 mL 9.1656 mL
15 mM 0.2444 mL 1.2221 mL 2.4442 mL 6.1104 mL
20 mM 0.1833 mL 0.9166 mL 1.8331 mL 4.5828 mL
25 mM 0.1466 mL 0.7332 mL 1.4665 mL 3.6662 mL
30 mM 0.1222 mL 0.6110 mL 1.2221 mL 3.0552 mL
40 mM 0.0917 mL 0.4583 mL 0.9166 mL 2.2914 mL
50 mM 0.0733 mL 0.3666 mL 0.7332 mL 1.8331 mL
60 mM 0.0611 mL 0.3055 mL 0.6110 mL 1.5276 mL
80 mM 0.0458 mL 0.2291 mL 0.4583 mL 1.1457 mL
100 mM 0.0367 mL 0.1833 mL 0.3666 mL 0.9166 mL
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Moclobemide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moclobemide-d4Ro111163-d4Monoamine OxidaseMAOInhibitorinhibitorinhibit

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