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MO-I-500 is a pharmacological of FTO inhibitor with an IC50 of 8.7 μM for the inhibition of purified FTO demethylase catalyzing demethylation of an artificial small methylated substrate. MO-I-500 can be used for the research of rare panresistant triple-negative inflammatory breast cancer.

For research use only. We do not sell to patients.

MO-I-500 Chemical Structure

MO-I-500 Chemical Structure

CAS No. : 1585219-04-0

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Based on 1 publication(s) in Google Scholar

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Description

MO-I-500 is a pharmacological of FTO inhibitor with an IC50 of 8.7 μM for the inhibition of purified FTO demethylase catalyzing demethylation of an artificial small methylated substrate. MO-I-500 can be used for the research of rare panresistant triple-negative inflammatory breast cancer[1].

Molecular Weight

317.75

Formula

C12H12ClNO5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCS(=O)(NC1=C(C(O)=C(O1)C2=CC=C(C=C2)Cl)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.8 mg/mL (100.08 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1471 mL 15.7356 mL 31.4713 mL
5 mM 0.6294 mL 3.1471 mL 6.2943 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1471 mL 15.7356 mL 31.4713 mL 78.6782 mL
5 mM 0.6294 mL 3.1471 mL 6.2943 mL 15.7356 mL
10 mM 0.3147 mL 1.5736 mL 3.1471 mL 7.8678 mL
15 mM 0.2098 mL 1.0490 mL 2.0981 mL 5.2452 mL
20 mM 0.1574 mL 0.7868 mL 1.5736 mL 3.9339 mL
25 mM 0.1259 mL 0.6294 mL 1.2589 mL 3.1471 mL
30 mM 0.1049 mL 0.5245 mL 1.0490 mL 2.6226 mL
40 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.9670 mL
50 mM 0.0629 mL 0.3147 mL 0.6294 mL 1.5736 mL
60 mM 0.0525 mL 0.2623 mL 0.5245 mL 1.3113 mL
80 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.9835 mL
100 mM 0.0315 mL 0.1574 mL 0.3147 mL 0.7868 mL
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MO-I-500 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MO-I-5001585219-04-0OthersFTOFTO demethylasetriple-negative inflammatory breast cancerInhibitorinhibitorinhibit

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