2. Academic Validation
  3. Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast

Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast

  • Mutat Res. 1998 Jun 18;402(1-2):41-50. doi: 10.1016/s0027-5107(97)00280-7.
S G Kozmin 1,  R M Schaaper,  P V Shcherbakova,  V N Kulikov,  V N Noskov,  M L Guetsova,  V V Alenin,  I B Rogozin,  K S Makarova,  Y I Pavlov
Affiliations

Affiliation

  • 1 Department of Genetics, Sankt-Petersburg University, Sankt-Petersburg, 199034, Russian Federation.
PMID: 9675240 DOI: 10.1016/s0027-5107(97)00280-7
Abstract

Base analog 6-N-hydroxylaminopurine is a potent mutagen in variety of prokaryotic and eukaryotic organisms. In the review, we discuss recent results of the studies of HAP mutagenic activity, genetic control and specificity in bacteria and yeast with the emphasis to the mechanisms protecting living cells from mutagenic and toxic effects of this base analog.

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