2. Academic Validation
  3. The Efficacy of Cholesterol-Based Carriers in Drug Delivery

The Efficacy of Cholesterol-Based Carriers in Drug Delivery

  • Molecules. 2020 Sep 22;25(18):4330. doi: 10.3390/molecules25184330.
Ngonidzashe Ruwizhi 1,  Blessing Atim Aderibigbe 1
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa.
PMID: 32971733 DOI: 10.3390/molecules25184330
Abstract

Several researchers have reported the use of cholesterol-based carriers in drug delivery. The presence of Cholesterol in cell membranes and its wide distribution in the body has led to it being used in preparing carriers for the delivery of a variety of therapeutic agents such as Anticancer, antimalarials and antivirals. These cholesterol-based carriers were designed as micelles, nanoparticles, copolymers, liposomes, etc. and their routes of administration include oral, intravenous and transdermal. The biocompatibility, good bioavailability and biological activity of cholesterol-based carriers make them potent prodrugs. Several in vitro and in vivo studies revealed cholesterol-based carriers potentials in delivering bioactive agents. In this manuscript, a critical review of the efficacy of cholesterol-based carriers is reported.

Keywords

antibacterial; anticancer; antiviral; cholesterol; drug delivery system; wound dressing.

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