2. Academic Validation
  3. A new flavone glucoside together with known ellagitannins and flavones with anti-diabetic and anti-obesity activities from the flowers of pomegranate (Punica granatum)

A new flavone glucoside together with known ellagitannins and flavones with anti-diabetic and anti-obesity activities from the flowers of pomegranate (Punica granatum)

  • Nat Prod Res. 2019 Jan;33(2):252-257. doi: 10.1080/14786419.2018.1446009.
Sheng Wu 1 2,  Li Tian 1 2 3
Affiliations

Affiliations

  • 1 a Shanghai Key Laboratory of Plant Functional Genomics and Resources , Shanghai Chenshan Botanical Garden , Shanghai , China.
  • 2 b Shanghai Chenshan Plant Science Research Centre , Chinese Academy of Sciences , Shanghai , China.
  • 3 c Department of Plant Sciences , University of California , Davis , CA , USA.
PMID: 29502447 DOI: 10.1080/14786419.2018.1446009
Abstract

A new flavone glucoside tricetin 4'-O-β-glucopyranoside (1) and four known ellagitannins and Flavones tricetin (2), luteolin (3), ellagic acid (4), and granatin B (5) were isolated from the flowers of Punica granatum L. (Lythraceae). Their structures were established by 1D and 2D NMR as well as mass spectrometry analyses. Among all tested compounds, tricetin (2) exhibited the strongest α-glucosidase inhibitory activity that was comparable to the anti-diabetic drug acarbose. Comparative structure-function analysis of tri-, tetra-, and pentahydroxy Flavones [apigenin, luteolin (3), and tricetin (2), respectively] suggested that a greater number of hydroxyl groups on the flavone molecule enhanced its suppression of α-glucosidase, α-amylase, and Lipase activities.

Keywords

anti-diabetic; anti-obesity; flower; lythraceae.

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