2. Academic Validation
  3. Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata

Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata

  • Chem Pharm Bull (Tokyo). 2006 Sep;54(9):1344-6. doi: 10.1248/cpb.54.1344.
Parinuch Chumkaew 1,  Shigeru Kato,  Kan Chantrapromma
Affiliations

Affiliation

  • 1 School of Science and Research Unit of Natural Products Utilization, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand.
PMID: 16946551 DOI: 10.1248/cpb.54.1344
Abstract

Two new rocaglamide derivatives, 1-O-formylrocagloic acid (1) and 3'-hydroxy rocagloic acid (2), together with five known compounds, rocaglaol (3), rocagloic acid (4), 3'-hydroxymethylrocaglate (5), 1-O-formylmethyl rocaglate (6), and methylrocaglate (7), were isolated from the fruits of Amoora cucullata. Their structures were elucidated by spectroscopic methods. Compounds 1-3, 6, and 7 exhibited potent cytotoxicity against KB, BC, and NCI-H187 cell lines, whereas 4 and 5 showed selective cytotoxicity against NCI-H187 cell line.

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