Lucicebtide acetate 

Lucicebtide acetate is the acetate salt form of Lucicebtide (HY-P10376). Lucicebtide acetate is a selective antagonist for CCAAT/enhancer binding protein β (C/EBPβ). Lucicebtide acetate binds to the leucine zipper domain of C/EBPβ, prevents its dimerization, and ubiquitin-dependently degrades C/EBPβ. Lucicebtide acetate arrests cell cycle at G0/G1 phase. Lucicebtide acetate exhibits cytotoxicity in cancer cells. Lucicebtide acetate exhibits good pharmacokinetic characters and inhibits tumor growth in mouse model^[1].

4724.46 (free base)

C₂₀₈H₃₄₅N₆₉O₅₅S.xC₂H₄O₂

d-{Val-Ala-Glu-Ala-Arg-Glu-Glu-Leu-Glu-Arg-Leu-Glu-Ala-Arg-Leu-Gly-Gln-Ala-Arg-Gly-Glu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Leu-Lys-Leu-Gln-Arg}

d-{Val-Ala-Glu-Ala-Arg-Glu-Glu-Leu-Glu-Arg-Leu-Glu-Ala-Arg-Leu-Gly-Gln-Ala-Arg-Gly-Glu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Leu-Lys-Leu-Gln-Arg}

CC(O)=O.N=C(NCCC[C@@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC(CNC([C@H](NC([C@H](NC([C@H](NC(CNC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](N)C(C)C)=O)C)=O)CCC(O)=O)=O)C)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCC(O)=O)=O)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)CCC(N)=O)=O)C)=O)CCCNC(N)=N)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CCCCN)=O)CCCCN)=O)CC1=CNC2=C1C=CC=C2)=O)CCCCN)=O)CCSC)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CNC5=C4C=CC=C5)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CCC(N)=O)=O)C(O)=O)N.[x]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Darvishi E, et al., Anticancer Activity of ST101, A Novel Antagonist of CCAAT/Enhancer Binding Protein β. Mol Cancer Ther. 2022 Nov 3;21(11):1632-1644.  [Content Brief]