2. Immunology/Inflammation Apoptosis
  3. COX Apoptosis
  4. Ketoprofen-d4

Ketoprofen-d4  (Synonyms: RP-19583-d4)

Cat. No.: HY-B0227S1 Purity: ≥98.0%
COA Handling Instructions

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Ketoprofen-d4 is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

For research use only. We do not sell to patients.

Ketoprofen-d<sub>4</sub> Chemical Structure

Ketoprofen-d4 Chemical Structure

CAS No. : 1219805-29-4

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1 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ketoprofen-d4:

Ketoprofen-d4 Related Antibodies

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Description

Ketoprofen-d4 is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ketoprofen-d4 Related Antibodies
Molecular Weight

258.31

Formula

C16H10D4O3
CAS No.
Unlabeled Cas

22071-15-4
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)C2=CC(C(C([2H])([2H])[2H])([2H])C(O)=O)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (387.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.39 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8713 mL 19.3566 mL 38.7132 mL
5 mM 0.7743 mL 3.8713 mL 7.7426 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8713 mL 19.3566 mL 38.7132 mL 96.7829 mL
5 mM 0.7743 mL 3.8713 mL 7.7426 mL 19.3566 mL
10 mM 0.3871 mL 1.9357 mL 3.8713 mL 9.6783 mL
15 mM 0.2581 mL 1.2904 mL 2.5809 mL 6.4522 mL
20 mM 0.1936 mL 0.9678 mL 1.9357 mL 4.8391 mL
25 mM 0.1549 mL 0.7743 mL 1.5485 mL 3.8713 mL
30 mM 0.1290 mL 0.6452 mL 1.2904 mL 3.2261 mL
40 mM 0.0968 mL 0.4839 mL 0.9678 mL 2.4196 mL
50 mM 0.0774 mL 0.3871 mL 0.7743 mL 1.9357 mL
60 mM 0.0645 mL 0.3226 mL 0.6452 mL 1.6130 mL
80 mM 0.0484 mL 0.2420 mL 0.4839 mL 1.2098 mL
100 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.9678 mL
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Ketoprofen-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ketoprofen-d41219805-29-4RP-19583-d4COXApoptosisCyclooxygenaseInhibitorinhibitorinhibit

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