1. NF-κB
  2. Keap1-Nrf2
  3. Keap1-Nrf2-IN-20

Keap1-Nrf2-IN-20 (Compound ZC9) is an inhibitor for Keap-Nrf2 pathway with KD2 of 51 nM. Keap1-Nrf2-IN-20 exhibits good cell permeability, cell activity, and metabolic stability (serum t1/2 > 24 h).

For research use only. We do not sell to patients.

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Keap1-Nrf2-IN-20 Chemical Structure

Keap1-Nrf2-IN-20 Chemical Structure

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Description

Keap1-Nrf2-IN-20 (Compound ZC9) is an inhibitor for Keap-Nrf2 pathway with KD2 of 51 nM. Keap1-Nrf2-IN-20 exhibits good cell permeability, cell activity, and metabolic stability (serum t1/2 > 24 h)[1].

In Vitro

Keap1-Nrf2-IN-20 (15-60 μM) inhibits expressions of TNF-α and IL-6 in LPS (HY-D1056)-induced inflammation in mouse peritoneal macrophages, exhibits anti-inflammatory efficacy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Keap1-Nrf2-IN-20 (20-80 mg/kg, tail vein injection, single dose) attenuates LPS-induced acute lung injury in C57BL/6 mice model[1].
Keap1-Nrf2-IN-20 (56 mg/kg, iv, single dose) exhibits a satisfactory pharmacokinetic profils in Sprague Dawley rats, the half time (T1/2), clearance rate (CL), area under curve (AUC) and apparent distribution volume (V) are 0.22 h, 3.90 L/h/kg, 14344.57 h·ng/mL and 1.26 L/kg, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced acute lung injury in C57BL/6 mice model[1]
Dosage: 20-80 mg/kg
Administration: tail vein injection, single dose
Result: Maintained intact alveolar structure, reduced inflammatory cell infiltration, bleeding points or congestion.
Molecular Weight

1030.04

Formula

C42H67N11O19

Unlabeled Cas

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Keap1-Nrf2-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Keap1-Nrf2-IN-20
Cat. No.:
HY-158055
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