2. Anti-infection Autophagy
  3. Bacterial Autophagy Mitophagy Antibiotic
  4. Isoniazid-d4

Isoniazid-d4  (Synonyms: INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4)

Cat. No.: HY-B0329S Purity: 98.95%
COA Handling Instructions

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Isoniazid-d4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

For research use only. We do not sell to patients.

Isoniazid-d<sub>4</sub> Chemical Structure

Isoniazid-d4 Chemical Structure

CAS No. : 774596-24-6

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1 mg USD 400 In-stock
5 mg USD 1380 In-stock
10 mg USD 2280 In-stock
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Based on 1 publication(s) in Google Scholar

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Isoniazid-d4 Related Antibodies

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Description

Isoniazid-d4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isoniazid-d4 Related Antibodies
Molecular Weight

141.16

Formula

C6H3D4N3O
CAS No.
Unlabeled Cas

54-85-3
Appearance

Solid

Color

White to off-white

SMILES

NNC(C1=C([2H])C([2H])=NC([2H])=C1[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (354.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 33.33 mg/mL (236.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.0842 mL 35.4208 mL 70.8416 mL
5 mM 1.4168 mL 7.0842 mL 14.1683 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 7.0842 mL 35.4208 mL 70.8416 mL 177.1040 mL
5 mM 1.4168 mL 7.0842 mL 14.1683 mL 35.4208 mL
10 mM 0.7084 mL 3.5421 mL 7.0842 mL 17.7104 mL
15 mM 0.4723 mL 2.3614 mL 4.7228 mL 11.8069 mL
20 mM 0.3542 mL 1.7710 mL 3.5421 mL 8.8552 mL
25 mM 0.2834 mL 1.4168 mL 2.8337 mL 7.0842 mL
30 mM 0.2361 mL 1.1807 mL 2.3614 mL 5.9035 mL
40 mM 0.1771 mL 0.8855 mL 1.7710 mL 4.4276 mL
50 mM 0.1417 mL 0.7084 mL 1.4168 mL 3.5421 mL
60 mM 0.1181 mL 0.5903 mL 1.1807 mL 2.9517 mL
80 mM 0.0886 mL 0.4428 mL 0.8855 mL 2.2138 mL
100 mM 0.0708 mL 0.3542 mL 0.7084 mL 1.7710 mL
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Isoniazid-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoniazid-d4774596-24-6INH-d4Isonicotinic acid hydrazide-d4Isonicotinic hydrazide-d4BacterialAutophagyMitophagyAntibioticMitochondrial AutophagyInhibitorinhibitorinhibit

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