2. Metabolic Enzyme/Protease Neuronal Signaling
  3. HIF/HIF Prolyl-Hydroxylase Monoamine Oxidase
  4. HIF-1α-IN-5

HIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer.

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HIF-1α-IN-5 Chemical Structure

HIF-1α-IN-5 Chemical Structure

CAS No. : 2826221-10-5

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Based on 1 publication(s) in Google Scholar

HIF-1α-IN-5 Related Antibodies

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Description

HIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer[1].

IC50 & Target

HIF-1α, MAO-A[1]
In Vitro

HIF-1α-IN-5 (compound 15, 24 h) shows inhibitory effects against HIF-1α transcription in HEK293T cells, with an IC50 value of 24 nM[1].
HIF-1α-IN-5 (0-50 μM, 24 h) downregulates VEGF and PDK1 mRNA expressions under hypoxia in HEK293T cells[1].
HIF-1α-IN-5 (10 μM) inhibits MAO-A activity activity by 80.64%, and ADORA2A by 43.95%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HIF-1α-IN-5 Related Antibodies

RT-PCR[1]

Cell Line: HEK293T cells under hypoxia
Concentration: 0-50 μM approximately
Incubation Time: 24 h
Result: Dose-dependently reduces VEGF and PDK1 mRNA expression.
Molecular Weight

281.31

Formula

C16H15N3O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(N(C)C)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (444.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5548 mL 17.7740 mL 35.5480 mL
5 mM 0.7110 mL 3.5548 mL 7.1096 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5548 mL 17.7740 mL 35.5480 mL 88.8699 mL
5 mM 0.7110 mL 3.5548 mL 7.1096 mL 17.7740 mL
10 mM 0.3555 mL 1.7774 mL 3.5548 mL 8.8870 mL
15 mM 0.2370 mL 1.1849 mL 2.3699 mL 5.9247 mL
20 mM 0.1777 mL 0.8887 mL 1.7774 mL 4.4435 mL
25 mM 0.1422 mL 0.7110 mL 1.4219 mL 3.5548 mL
30 mM 0.1185 mL 0.5925 mL 1.1849 mL 2.9623 mL
40 mM 0.0889 mL 0.4443 mL 0.8887 mL 2.2217 mL
50 mM 0.0711 mL 0.3555 mL 0.7110 mL 1.7774 mL
60 mM 0.0592 mL 0.2962 mL 0.5925 mL 1.4812 mL
80 mM 0.0444 mL 0.2222 mL 0.4443 mL 1.1109 mL
100 mM 0.0355 mL 0.1777 mL 0.3555 mL 0.8887 mL
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HIF-1α-IN-5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIF-1α-IN-52826221-10-5HIF/HIF Prolyl-HydroxylaseMonoamine OxidaseHypoxia-inducible factorsHIFsHIF-PHMAOTumorHEK293ThypoxiaVEGFPDK1MAO-AInhibitorinhibitorinhibit

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